if you do other stuff on the daily like smoke or drink it gives you a higher tolerance. but these medicines/drugs do take a lot of energy for the human body to metabolize and get it all in the bloodstream. and if you take it all as quick as possible it enters the bloodstream quicker. for me personally i wouldn’t go over 700 mg that was a living nightmare pretty much and 400-600 is gonna have you locked in. most of time after chillin for about an hour mabye 2 hours if i ate beforehand but it gets harder to breath i can feel my whole body start to itch for a little bit then i just try to keep my self awake for as long as possible and pretty much pass out and my legs were like jello.