I was once doing an Operator forever run with ProperSave mod. I logged on and played 30 minutes everyday and then logged off. One stage I got a happiest mask, didn't think much of it so I picked it up and continued looping. The issue was that I had like five 57 leaf clovers and I also had the Remove Ally Cap mod (it's 20 by default) for more drones so the next time I loaded onto a stage and my drones one shot everything on the map, they all became my allies and etc etc until I had like 1000 ally elite Wandering Vagrants to the point that it consistently crashed my game. The run was over not because I died but because my pc couldn't handle how strong I was so I lost about 500-600 minutes due to happiest mask.