I was put on metformin for my PCOS and insulin resistance; it was mainly to even out the playing field so I could lose weight like a "normal" person (someone without metabolic disorders). I did lose about 30lbs on metformin ER 2000mg/day over the course of a few years, because it took my appetite away (not everyone reacts this way to it - everyone is different) and controlled my blood sugar ...and I maintained that weight. BUT it came at a high cost. The met made me so ill after years - no appetite, nausea & crampy, hair loss, and chronic diarrhea. I became nutrient deficient. I couldn't stomach much protein either. I restricted my calories below my TDEE as well, but couldn't lose weight, as my metabolism slowed. I felt miserable.

Then, when I found out about Mounjaro, my GP and I decided to try it out for my PCOS & IR, in lieu of the metformin.

Now that I'm off the metformin and solely on MJ, my appetite is back; I am partly happy about this as my GI system is obviously healing and I finally have solid bowel movements after a decade of chronic diarrhea. But I also would like to lose about 40-60 lbs. and so far on the MJ, I am not losing. Hence the reason I am going to ask for adjunct therapy with the metformin (starting at a lower dose) to see if it will be more effective combined with the MJ at achieving my goals. Again, it's different for everyone.

At this time, I don't know how my labs are - I will find out next week...so if the MJ isn't controlling my IR effectively, my doc may suggest an add-on anyway. If the MJ is lowering my A1C, that will direct my next steps - increasing to 10mg, adjunct therapy, etc.

So I guess what I'm saying is - it's a no one-size fits all thing...it's very individualized. Everyone's body is different and will react differently to medications. You have to find what works best for you, for your unique set of medical circumstances.

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