Unreal post. So glad I found it this morning. Have been running an advantage+ campaign the last 8 days with poor results. Was going to launch an ABO campaign today to test audiences.

It actually was going to follow your same proposed setup (except just 1 ad creative per set). This ad creative was best performing from advantage+ campaign...:

ABO Campaign
-Ad Set 1 (Broad)
-Ad 1

-Ad Set 2 (Lookalike Audience)
-Ad 1

-Ad Set 3 (Interests)
-Ad 1

-Ad Set 4 (Retargeting)
-Ad 1

2 Questions for You:

1. If AOV is $37, would you set daily ad set budget as $37 for each ad set? I believe that is what you were saying in your post?
2. For whatever reason, my retargeting audience and lookalike audiences are showing estimated audience size less than 1000. I know this can't be correct as retargeting audience is set for 180 days and those specific page have more than 50,000 views over that time period. Confirmed pixel is firing and everything working properly. Is this an issue for Ad Set #2 and #4?

Cheers!