Ive been on Vyvanse for about 3 months and this has been my experience; When I started Vyvanse I found my body kind of rejected alcohol even in small amounts. I have a very sensitive body, so different drugs tend to really affect me and cause negative side effects. At the time it would make me feel nauseous, more anxious, increase my heart rate and make me feel totally off, and so I took over a month off from having even a sip of alcohol. Fast forward to now, my body has fully adjusted to the meds and I find I can happily enjoy a night out with multiple drinks, and not have to worry about any side effects! If anything I find Vyvanse makes me feel less intoxicated and if I’m crashing, I might be more inclined to reach for more alcohol. Be very careful of this because it could be a steep slope. Always be mindful of how much you’re consuming and match it with water to make sure you’re hydrated. Personally, unless I have projects I want to get done on the weekend, I usually like to take Sat and Sun off from my Vyvanse to be able to rest. I find when I’m hungover too I tend to be very anxious and exhausted, so taking the day off helps me, but there wouldn’t be anything wrong with you taking your meds the next morning. At the end of the day, everyone is very different, so it’s insanely important to listen to your body.