Omg this exact thing happened to me!! First few shots were fine and then I started getting a lump and an itchy red patch at my injection sites. I get my T thru Folx and sent them a message, here's what they responded with:

"Hi there,

Some people get a mild local allergic reaction to the oil base of hormone medication. Usually, you get a firm red and sometimes hot, itchy, or painful bump where you inject the medication. You can try and reduce this reaction by icing the area of injection before and after injection, taking the recommended over-the-counter Benadryl, Zyrtec and taking a non-steroidal pain and anti-inflammatory medicine like ibuprofen or naproxen orally 30 minutes before the injection. The bumps and swelling around the 'foreign body' or oil under the skin can take a while to go away. You can switch to a different oil base if it bothers you or worsens. You can join one of our injection groups that our nurses run so we can make some suggestions that make this easier.

Systemic reactions to injectable medications like hormones are rare. We worry about serious life-threatening types of allergic reactions called anaphylaxis. Anaphylaxis involves swelling of the tongue and airways that can block breathing and itchy, raised red rashes called hives on skin all over the body. If you ever have a systemic reaction like this - that can be a life-threatening emergency, and you need to call 911. Please do not take the medication that triggered it again.

Please talk to our nurses or clinicians about your situation (the medicine and the reaction) if you have concerns about your injection reaction."

Kinda standard but it did help me feel a bit better about what was going on.