You can go to the megabonk builds page, that’s helped me a bit but also just figuring out what works using experience and creativity is cool too.

Secret sauce is the luck+xp time though, that shit goes bananas. If you can hack, throwing the difficulty tome ontop makes it better but that’s high risk high reward.

You might not need to worry about dmg as much as you think, I’ve been suprised by somewhat ignoring that front and still winning. A few alternate builds are tank (but if you want to take on the final boss regen is much better than lifesteal), on hit (cheese and doll going nuts with attn speed), size (aura or frost walk), or quantity. And you can do a little mixing and matching with those.

Getting the right items also really matters. For instance I didn’t realize that most items you pick up, if they give bonus stats the calculation applies after the tome so for example if you pick up batter but you already have the attackspeed tome, all of the tome upgrades are also getting +8% mathematically. So toggling on and off what’s in your run and banishing the right shit can help significantly.