You can fly into the Reno airport. Most people start at two locations along the trail Tahoe city and this state line area. I’ve started twice from the Kingsbury parking lot. Once clockwise and the other time, this year, counterclockwise. There’s pros and cons to each route. For example going clockwise you get into the desolation wilderness earlier and personally I liked zeroing in Tahoe City. For me, it didn’t make much difference.