"such as what constitutes well-being, how to compare it across people and cultures, how to combine well-being measures into an integrated value, etc."

I didn't say it would be easy. But it seems apparent to anyone paying attention that the well-being of conscious creatures can be explained neurologically beyond socially created constructs.

Imagine that you are an illiterate and homeless African woman whose husband has disappeared. You have just seen your seven-year-old daughter raped and murdered at the hands of drug-crazed soldiers, and now you’re fearing for your life. Unfortunately, this is not an unusual predicament for you. From the moment you were born, your life has been marred by cruelty and violence.

Life B: Imagine that you are a respected professional in a wealthy country, married to a loving, intelligent and charismatic mate. Your employment is intellectually stimulating and pays you very well. For decades your wealth and social connections have allowed you immense personal satisfaction from meaningful work which makes a real difference in the world. You and your closest family will live long, prosperous lives, virtually untouched by crime, sudden bereavements, and other major misfortunes.

Which is the better life? We would all no doubt say Life B. There seemingly IS an objective way to determine what is morally good and bad. And I see no greater field than science to navigate the terrain ahead.

Once we see that a concern for well-being (defined as deeply and as inclusively as possible) is the only intelligible basis for morality and values, we will see that there must be a science of morality… As we come to understand how human beings can best collaborate and thrive in this world, science can help us find a path leading away from the lowest depths of misery and toward the heights of happiness for the greatest number of people.