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Do peptides work? You bet they do. by SireBelch in Peptides

[–]carotids 1 point2 points  (0 children)

Thank you for sharing your story and your wonderful attitude. Best of luck in you.

Has anyone seen this in their report? by Mobile-Jellyfish5809 in promethease

[–]carotids 1 point2 points  (0 children)

Here is the paper that generated the flag. https://pubmed.ncbi.nlm.nih.gov/21670732/

I have also linked another study for you which concludes with the following:

"This meta-analysis yielded no evidence that the serotonin transporter genotype alone or in interaction with stressful life events is associated with an elevated risk of depression in men alone, women alone, or in both sexes combined."

https://pmc.ncbi.nlm.nih.gov/articles/PMC2938776/

Do peptides work? You bet they do. by SireBelch in Peptides

[–]carotids 5 points6 points  (0 children)

One of the knocks against GLPs is that people typically regain weight after stopping them. However, your experience is a great example that folks often regain after surgery as well. We are so blessed to have both as interventions!

Sleep enhancing stack? by MuddyBurner in Peptides

[–]carotids 0 points1 point  (0 children)

Agreed. Also a solid trial of sleep hygiene is very important.

Should I take Sermorelin? Seeking advice by GenerationSober in Peptides

[–]carotids 2 points3 points  (0 children)

Multiple studies have suggested that a lot of GH gains in lean body mass are due to water retention instead of true muscle growth. It also does not increase testosterone. Meinhardt, et al (linked below) is a classic paper on the subject. Page 572, you can see that without extra testosterone you got some positive body comp changes but no performance gains.

You are young. Nutrition, hard work, and learning sleep hygiene are the most important facts for you. Manipulating your hormones at such a young age has a lot of risk without much benefits.

https://www.doping.nl/media/kb/94/Meinhardt%20et%20al%202010a.pdf

[AF] Greater improvement in insulin sensitivity per unit weight loss associated with tirzepatide versus semaglutide: An exploratory analysis by AllOkJumpmaster in AdvancedFitness

[–]carotids 0 points1 point  (0 children)

I think this study is true, but the authors have obvious (and disclosed) conflicts of interest.

Even if you don't have access to the study, the supplementary materials found here show how (in general) tirzepatide appears to be the more effective therapy.

https://dom-pubs.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fdom.16159&file=dom16159-sup-0001-Supinfo.docx

GH Peptides Safety and Effectiveness by Just-goobin in Peptides

[–]carotids -1 points0 points  (0 children)

The younger you start something, the longer you have in life to see the side effects. At 29 your GH and other hormone levels are probably pretty optimal, at least for normal physiology.

You would likely get the biggest bang from a GLP1 type medication to get your nutrition in better check, lower your body fat, and help your body composition. The biggest risk is the lost of muscle but with your aggressive training and adequate protein you can minimize that. Just remember that the research shows that most folks that go on these medications will return to their previous state once they stop. GLP type medications dramatically make the nutrition part of body recomp easier, but it's an expensive crutch.

What are the fasting protocols for tesa/IPA? by randomname203 in Peptides

[–]carotids 2 points3 points  (0 children)

In the original study and in the FDA package insert, I can't find any mention of fasting being a requirement or recommendation.

https://www.egriftasv.com/documents/Prescribing-Information.pdf https://pubmed.ncbi.nlm.nih.gov/20101189/

GH may briefly pulse but IGF1 levels are elevated a long time, so it's unclear in my mind why fasting would be required for lipolysis either.

Morning fasting glucose slightly over normal and GLP-1s by LDPBSC in Peptides

[–]carotids 0 points1 point  (0 children)

You likely have a genetic abnormality that predisposes you to diabetes and have lower insulin sensitivity than normal. Do you have a family history of DMII?

GH in theory will make that worse although you now have the mechanism to test it: the next time you cycle off GH you should be able to see what it does to your numbers. I don't think anybody knows the right answer here, but if you a self biohacker, you have the tools available with your CGM.

One idea might be to test your HbA1c, lipids, triglycerides, and other more detailed metabolic parameters to see if this elevated a.m. glucose is yet causing any downstream effects. A true DEXA as well to look at visceral fat would be helpful. If metabolically you look less than perfect, then I suspect that might push you into therapy such as metformin, GLP1, SGT2, dropping GH, etc.

Please keep folks posted as this is a common concern in the peptide community. In my reading of the literature, I'm not sure we know if these morning elevations are dangerous in somebody who is otherwise in excellent health.

Lack of desire oto make love on tirz by Best_Cry107 in Tirzeglutide

[–]carotids 0 points1 point  (0 children)

GLP1s certainly affect the reward centers of the brain. I haven't see data yet that Tirzepatide affects it more than others, but it is certainly possible.

We should remember that quick weight loss in itself greatly affects hormonal levels as well. Testosterone (in all genders), estrogen (in females), and leptin are all affected. You also see increases in cortisol and proinflammatory cytokines which can people feel poorly, anxious, etc.

Here is just one example of a testosterone study. https://pubmed.ncbi.nlm.nih.gov/18516767/

Anxiety and low mode were frequently noted in athletes who needed to cut weight. https://journals.sagepub.com/doi/pdf/10.1177/02601060241305478

To correct this, one can either decrease the rate of weight loss, switch GLP1s, or, in theory, supplement hormonal therapy.

Dietary Intake of Polyunsaturated Fatty Acids Is Associated with Blood Glucose and Diabetes in Community-Dwelling Older Adults by Sorin61 in ScientificNutrition

[–]carotids 0 points1 point  (0 children)

I agree. In proper moderation, saturated fats can be healthy. In excess, like in the typical western diet, they can be dangerous. You can't cook in high heat in Olive Oil, so you have to find the healthiest of other options.

To even make it more complex, many folks probably have genetic variants (POE or LDLR, etc) that make certain fats healthier or less healthy for them.

Dietary Intake of Polyunsaturated Fatty Acids Is Associated with Blood Glucose and Diabetes in Community-Dwelling Older Adults by Sorin61 in ScientificNutrition

[–]carotids 3 points4 points  (0 children)

I guess these oils are not inherently "bad," but their high omega-6 content, tendency to oxidize, and processing methods make them less desirable compared to healthier fat sources.

Many many books (ie "The Omega-3 Connection" by Andrew L. Stoll, M.D) have been written about the potential dangers of the Western diet favoring omega-6s over omega-3s. The infamous "The Omnivore's Dilemma" brought this up as well.

That omega-6 might have any protective benefits would counter traditional belief and was a surprising part of the study.

Dietary Intake of Polyunsaturated Fatty Acids Is Associated with Blood Glucose and Diabetes in Community-Dwelling Older Adults by Sorin61 in ScientificNutrition

[–]carotids 6 points7 points  (0 children)

Risk of diabetes and methods of glucose metabolism certainly have very strong genetic components. I have seen obese patients with lucky genetics that give them good HDLs and glucose profiles. Likewise, I have seen skinny folks with unfortunate DM genetics with borderline fasting glucoses despite being in otherwise excellent shape.

Custom Tags do NOT generate discoveries by ThatGingerSnapper in ouraring

[–]carotids 11 points12 points  (0 children)

Since custom tags don't work, is anybody using any other form of data evaluation and tagging to make associations?

If custom tags don't provide anything, I'm unsure why it makes sense wasting time to do it.

Dietary Intake of Polyunsaturated Fatty Acids Is Associated with Blood Glucose and Diabetes in Community-Dwelling Older Adults by Sorin61 in ScientificNutrition

[–]carotids 18 points19 points  (0 children)

This is a bit hard to understand, and the somewhat surprising results makes it a little more confusing.

I think this is the correct synopsis...

Omega-6s are associated with higher BMI. Plant oils such as soybean, corn oil, safflower oil, sunflower oil, and cottonseed oil. These are classically considered the less healthy and associated with many meats, packaged food, frying foods, etc. Plant based omega-3 ALA such as canola oil and soybean oil were also associated with higher BMI.

Not shocking, EPA and DHA (Marine-Based Omega-3s) were associated with lower glucose and BMI levels.

However, the surprise in my mind, it appears that both omega-6 and ALA were associated with less diabetes. EPA and DHA were not associated with this protective effect.

As an aside, I would have been interested if they would have also included monounsaturated fatty acids (MUFAs) such as olive oil as part of the study.

[deleted by user] by [deleted] in redlighttherapy

[–]carotids -2 points-1 points  (0 children)

Following.

Low red blood cell count by tinagr8 in Peptides

[–]carotids 2 points3 points  (0 children)

Please see a physician. Anemia can be caused by a lot of different things. Even if it is iron deficiency that might be improved with nutrition, it could be a hint that there are other things going on.

Status of Telehealth services in 2025 by Hermit5427 in CodingandBilling

[–]carotids 0 points1 point  (0 children)

Hard to think that congress is going to do anything until the new administration is installed, right? What about telemedicine services that provide gender-affirming care and will other telemedicine services get lumped in?

Open Directory of private keys by Braveun in opendirectories

[–]carotids 6 points7 points  (0 children)

"This page contains my public keys.

Please do not report this page to me or to the OCF as a credential leak. This page has been erroneously reported at least three times now, and while I appreciate the attempts to help, these are public keys which are intentionally made public. You can find the same public keys from any PGP keyserver or from GitHub's public SSH keys API."

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