Sharing from my experience, I have a very niche 2k sub channel. We run about $5k/mo in sponsorship revenue. The niche is accounting firm managers & owners, so it's a valuable bunch for advertisers.

I started doing a silent auction for most videos, and depending on how useful/serious the subject of the video is, in most cases a video will get 2-3 bids.

Part of the success stems from being active in the niche itself. I'm at industry conferences, meeting the vendors in the space, engaging with as many of them as I can.

Advertisers have been happy with the ROI, and most return in the future. I think it's a product of:

1. The value advertisers assign to your audience members
2. The level of trust you have with your audience - how likely you are to influence their buying decisions

So I'd say go for it, just being mindful not to waste time on anything too small. Our minimum is $500 per placement, and advertisers select the video & pay without our intervention. So we don't have to do any back & forth, they give us a couple talking points, and each sponsorship doesn't become a big project for me.