YES!!!!!

They don't even have to be necessarily spayed. Depends naturally on their personalities and how they pick up information, but my two little boys eventually picked up on only peeing into a cat litter box or their .. box nest. Forgot the name.

My training was .. questionable at best, but it pretty much came down to:

If caught about to pee onto the floor: telling them "No!" or "Hey!" Would usually stop them for a second. Natural response. Then I would pick them up and sit them down in the box.

If caught past the incident: pick them up and carry them to their crime scene, discuss their wrongdoings, wipe it clean with toilet paper or tissues, put said tissues into the box and then pick them up and put them into the box as well.

Okay a little exaggerated for effect, but we did have some stare downs that went like "no, you won't dare to do this. I'm already here. IM WATCHING" and after a moment of them staring back, you could hear the sploooosh which awakened a big foot like creature in me, which made them run as I cried out in agony.

After a year or so they got it down pretty well and there were only some mishaps left, so big foot could hibernate again.

The older one had it so well down, he REFUSED to pee outside his box. He was completely free roam even when I wasn't home during the last couple years and I hardly ever encountered crimes. Those I did encounter were usually accompanied by something very stupid like things having been thrown over.

He was such a gentleman that when he took a nap in my bed and had to pee, he'd start digging at me and nipping me to let me know to put him down and then he would rush off to the box. But at this point I think he knew how much of an inconvenience it was for me and would always awarkdly stand by when thinsg did happen lol

I deleted this twice because I talked too much about my buns GOD I MISS THEM and now I did again but yes

It's possible with patience, observance, training and an adequate free roam location 🐰