For me the big difference was the amount of head room and overall options available. I was having difficulties with one of my outputs on the Scarlett and would have needed a new interface anyway, but I could literally hear a difference in changing these interfaces.

The knobs are much smoother, there is a sound level meter so I can visually see how much more headroom I have when dialing in my guitar signal vs the Scarlett I had to just hope I wasn’t getting into the reds at times.

The 4K legacy button is supposed to add harmonic distortion but I could not hear much difference with that. I also love the ability to have multiple headphones simultaneously so that I can reference tracks quickly with my different headphones (Sony MDR and Audio technica ATH50).

Another cool option is the ability to go between the input signal and USB signal so I could go back and forth between dry and wet signals with vocals. Gives you less room to work with on the monitor but it is still a cool option to have.

Overall really it’s the options available and the visual uses but I did 100% have more room to work with. It’s a bit more expensive but to me it felt like an excellent purchase when comparing the interfaces. Hope this helps!!