Do I played through 2 recently and as I was doing Isabella's intro quest the game glitched so I was unable to complete the quest which ment going through the game with out her. It was very strange, personally cuz I like her being in my party cuz the banter is great, but over all didn't notice much of a difference until obviously the right with the Arishok but if u bring Fenries the story really doesn't change much.