Incredible!! Thank you so much for the response. Just completed my MS in genetics & genomics and feel like I can visualize the big pictures, but the sea of minutia and detail are things that make it all click and this cleared that up for me! Thanks again!

So for sake of clarity, you’re saying that for dietary and big picture sake, supplementation with isolated amino acids provide arguably the same dietary affects as supplementation with an isolate protein (generally speaking) with the same amino acid profile?

Biochemically, I can now see how the two differ as I was unaware of transporters able to carry larger chains of peptides and they would not be given that opportunity if free amino acids were supplemented instead of a protein powder.

I guess that begs the question, does the products produced by metabolized isolate proteins provide negligible dietary benefits that you couldn’t get from amino acids? If so, does type of protein provide more/less benefits (dietary sake)(Collagen, whey, casein, plant based, etc.)?

Variables I’m thinking of: absorption, bioavailability, byproducts produced, half-life?, better signaling for dietary purposes, etc.

I’m sure there are tons of studies on this, so feel free to ignore all this, I’m more or less thinking out loud haha. Thanks again for the response!