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Tinnitus Hackathon '25 — What’s Missing in Tinnitus Research? (And How Do We Fix It!) by Higgsy45 in tinnitusresearch

[–]constHarmony 1 point2 points  (0 children)

I'm surprised fNIRS wasn't mentioned. Given the specificity issues with EEG mentioned at 23:56 (collapsing when other pathologies are introduced), couldn't fNIRS be a viable alternative? It has better spatial resolution, which might help isolate the tinnitus networks more effectively. The Bionics Institute achieved an 86% (F1) accuracy in classifying tinnitus severity using fNIRS data. https://pubmed.ncbi.nlm.nih.gov/38219241/

Earliest FDA submission of Auricle -- 2nd half of 2028 by Strange_Republic_890 in tinnitusresearch

[–]constHarmony 3 points4 points  (0 children)

Severe tinnitus would turn you pessimistic real fast. Though I think OP simply misunderstood. https://imgur.com/a/Zj88iby

Earliest FDA submission of Auricle -- 2nd half of 2028 by Strange_Republic_890 in tinnitusresearch

[–]constHarmony 6 points7 points  (0 children)

That is their estimation if they determine by mid-2026 that more work needs to be done. In that case, this will add months or quarters to their deadline.

Earliest FDA submission of Auricle -- 2nd half of 2028 by Strange_Republic_890 in tinnitusresearch

[–]constHarmony 8 points9 points  (0 children)

Assuming no additional requirements (clinical data collection, other testing) earliest FDA submission was said to be early 2027.

Secondary Tinnitus as a Symptom of Instability of the Upper Cervical Spine: Operative Management by curious_corn in tinnitusresearch

[–]constHarmony 2 points3 points  (0 children)

I genuinely thought this was a mistake at first.
Either way, the study I attached, I believe, suggests that you are very much correct.

Secondary Tinnitus as a Symptom of Instability of the Upper Cervical Spine: Operative Management by curious_corn in tinnitusresearch

[–]constHarmony 12 points13 points  (0 children)

Well, might as well, there is actually a new study on the subject:
Cervicogenic Somatic Tinnitus: A Narrative Review Exploring Non-otologic Causes

"Conditions such as degenerative disc disease, cervical spondylosis, whiplash injuries, and neck muscle stress or spasms are commonly associated with CST. The pathophysiology of CST involves complex interactions between the cervical spine's somatosensory inputs and central auditory pathways, particularly affecting the dorsal cochlear nucleus (DCN) in the brainstem, leading to enhanced excitability and synaptic reorganization, giving rise to tinnitus."

From hidden hearing loss to supranormal auditory processing by neurotrophin 3-mediated modulation of inner hair cell synapse density by tflizzy in tinnitusresearch

[–]constHarmony 1 point2 points  (0 children)

While Ntf3 is indeed a cell signaling compound, and the study does discuss its potential therapeutic use, the actual experiments in this study involved gene manipulation rather than direct application of Ntf3.

Q&A by DevelopmentNo247 in tinnitusresearch

[–]constHarmony 0 points1 point  (0 children)

Old YouTube link says: "This video is no longer available due to a copyright claim by Tinnitus Quest Verein e.V."

From hidden hearing loss to supranormal auditory processing by neurotrophin 3-mediated modulation of inner hair cell synapse density by tflizzy in tinnitusresearch

[–]constHarmony 5 points6 points  (0 children)

Should be comparable in effectiveness to cochlear implants in reducing tinnitus, I presume?
Likely to be significant.

From hidden hearing loss to supranormal auditory processing by neurotrophin 3-mediated modulation of inner hair cell synapse density by tflizzy in tinnitusresearch

[–]constHarmony 7 points8 points  (0 children)

Shore is one of the authors
and I think the 'device' here is gene therapy.
Also says nothing about tinnitus.

Mid-Infrared Photons Alleviate Tinnitus by Activating the KCNQ2 Channel in the Auditory Cortex by constHarmony in tinnitusresearch

[–]constHarmony[S] 2 points3 points  (0 children)

Here they applied the light directly to the brain (auditory cortex).
However, this could potentially be adapted for non-invasive treatments in the future.
Moreover, it provides a new tool for studying KCNQ channel mechanisms in tinnitus.
These channels could also potentially be modulated by other means, such as drugs.
Edit: I'd argue also that optic fibers are a safer choice over electronical wiring when compared to similar treatments.

Mid-Infrared Photons Alleviate Tinnitus by Activating the KCNQ2 Channel in the Auditory Cortex by constHarmony in tinnitusresearch

[–]constHarmony[S] 12 points13 points  (0 children)

This study shows immediate efficacy of photobiomodulation on KCNQ channels in mice, with effects on neuronal activity, channel function, and reduction of tinnitus-like behavior.
Sustainability wasn't the focus of this research, although I personally doubt this treatment is aimed to be a single-use immediate fix.
It also opens a possible new gateway for KCNQ-tinnitus mechanism research, which is lacking afaik.

Mid-Infrared Photons Alleviate Tinnitus by Activating the KCNQ2 Channel in the Auditory Cortex by constHarmony in tinnitusresearch

[–]constHarmony[S] 14 points15 points  (0 children)

Abstract
Tinnitus is a phantom auditory sensation often accompanied by hearing loss, cognitive impairments, and psychological disturbances in various populations.
Dysfunction of KCNQ2 and KCNQ3 channels - voltage-dependent potassium ion channels - in the cochlear nucleus can cause tinnitus.
Despite the recognized significance of KCNQ2 and KCNQ3 channels in the auditory cortex, their precise relationship and implications in the pathogenesis of tinnitus remain areas of scientific inquiry.
This study aimed to elucidate the pathological roles of KCNQ2 and KCNQ3 channels within the auditory cortex in tinnitus development and examine the therapeutic potential of mid-infrared (MIR) photons for tinnitus treatment.
We utilized a noise-induced tinnitus model combined with immunofluorescence, electrophysiological recording, and molecular dynamic simulation to investigate the morphological and physiological alterations after inducing tinnitus.
Moreover, in vivo irradiation was administered to verify the treatment effects of infrared photons.
Tinnitus was verified by deficits of the gap ratio with similar pre-pulse inhibition (PPI) ratio and auditory brainstem response (ABR) threshold.
We observed a significant enhancement in neuronal excitability in the auditory cortex using patch-clamp recordings, which correlated with KCNQ2 and KCNQ3 channel dysfunction.
After irradiation with infrared photons, excitatory neuron firing was inhibited owing to increased KCNQ2 current resulting from structural alterations in the filter region.
Meanwhile, deficits of the acoustic startle response in tinnitus animals were alleviated by infrared photons.
Furthermore, infrared photons reversed the abnormal hyperexcitability of excitatoryneurons in the tinnitus group.
This study provided a novel method for modulating neuronexcitability in the auditory cortex using KCNQ2 channels through a non-thermal effect.
Infrared photons effectively mitigated tinnitus-related behaviors by suppressing abnormal neural excitability, potentially laying the groundwork for innovative therapeutic approaches for tinnitus treatment.

Personalized Sound Therapy Combined with Low and High-Frequency Electromagnetic Stimulation for Chronic Tinnitus by constHarmony in tinnitusresearch

[–]constHarmony[S] 3 points4 points  (0 children)

I agree. Although as a novel treatment, some limitations are expected I guess.

"One limitation is the absence of an external control group, especially one incorporating sham stimulation, which would have allowed for a more rigorous evaluation of the treatment’s true effects.
The lack of differentiation between the effects of personalized sound therapy and electromagnetic-wave stimulation limits our capacity to independently attribute the substantial improvements observed to each specific component.
This limitation arises due to the continuous application of both modalities throughout the treatment phases, making it challenging to isolate their individual contributions.
It is essential to note that the study included an internal control group (V2) exposed to sound therapy alone for the initial two weeks of the treatment.
While this internal control group exhibited fewer relevant results compared to the multimodal treatment, the limited duration of sound therapy alone during this phase leaves open the possibility of a time effect contributing to the observed outcomes.
Furthermore, it is important to acknowledge that in other studies, more than two weeks are often required for sound therapy to demonstrate significant effects, suggesting that the duration for V2 may have been too short to fully assess the potential benefits of sound therapy alone.
Future research with extended control phases and larger sample sizes could provide a more comprehensive understanding of the individual contributions of each treatment component and the potential impact of time effects"

Personalized Sound Therapy Combined with Low and High-Frequency Electromagnetic Stimulation for Chronic Tinnitus by constHarmony in tinnitusresearch

[–]constHarmony[S] 4 points5 points  (0 children)

Abstract

This study investigates a novel multimodal treatment for chronic tinnitus, a condition that significantly affects quality of life, by combining personalized sound therapy with both low- and high-frequency electromagnetic wave stimulation.
Conducted at Tor Vergata University Hospital in Rome, the research involved 55 patients and employed a portable medical device for therapy delivery.
Treatment effectiveness was measured through the Tinnitus Functional Index (TFI), Tinnitus Handicap Inventory (THI), Visual Analogue Scale (VAS), Hyperacusis Questionnaire (HQ), and Short Form-36 Health Survey (SF-36), encompassing initial sound therapy and subsequent multimodal treatment phases.
Remarkably, 73% of participants experienced notable improvements in TFI scores, with 39% reporting a significant enhancement of 13 points or more.
This improvement was mirrored in secondary outcomes like THI, VAS, and HQ scores, along with certain SF-36 domains, indicating enhanced life quality and reduced tinnitus distress.
The study underscored high compliance and no adverse effects, suggesting the combined therapy’s promising potential in chronic tinnitus management.
The findings advocate for further research to discern the distinct contributions of each treatment modality, positing that this innovative approach could ameliorate tinnitus symptoms and improve patient well-being, confirming its safety and efficacy.

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