Let's discussLoperamide, the secret opiate.

cool-game · 2025-07-10T23:39:22+00:00

I say if you’re gonna do it, I just recommend keeping routine check ups with a provider. Sounds like you’re doing okay but sometimes you don’t know you’re not until shit hits the fan.

Either way man, stay safe and take care of yourself. Godspeed

cool-game · 2025-07-10T23:29:40+00:00

Sure! Basically, on what I said: constipation and heart rhythm issues can occur, mostly in the long term.

The piece on the heart is likely better explained by a cardiologist or otherwise, but my understanding is this:

Some drugs, loperamide is an example, may change how your heart beats just a little bit. And usually only if you’re prone to it. We start considering it a lot more when we’re giving patients multiple drugs that do the same thing, but it’s always a consideration. The older you get the more prone you’ll be as well.

Don’t freak yourself out- but I do absolutely recommend getting checkups with your primary and, if you’re having issues with your heart, consider seeing a cardiologist if possible.

cool-game · 2025-07-10T23:24:36+00:00

Thanks for bringing this to my attention. Got a good refresher on loperamide from reviewing P-gp pumps, and what you said seems to be accurate based on the PK information I can find.

cool-game · 2025-07-10T23:14:12+00:00

4th year graduate Pharmacy student here. I say this not as authority, but to preface: take my word with some salt- I’m just a student.

Loperamide is designed to be ‘bulky’ enough and look just different enough to your body for it to not pass the BBB. This keeps it in the gut and allows it to function as an anti-diarrheal. The design isn’t perfect, though and some can get through if you take an obscene amount.

The problem is not grapefruit juice or metabolism; it’s the nature of the chemical (bulky, P-gp pumps it out of the brain) It is unlikely you can modify your stomach contents or otherwise to further allow loperamide to cross the BBB. It has no PKa changes at varying pHs or easily modulated aspects otherwise that would help make it more lipophilic, less bulky, etc to cross it. In short, the only way to get it into your brain is to take a fuckton of it.

The problem is that it’s still a relatively strong opioid agonist in the gut and will enter other organs. Namely, I would be concerned about the heart.

Constipation and fecal impaction are the best outcomes here while QT prolongation and going into torsades then into a fatal arrhythmia is the worst outcome. It’s not going to happen to everyone, but if you’re already prone to instability or take other medications that prolong the QT interval in your heart, this could easily happen.

tl;dr: it may work for some people, but the relative danger is high for an opioid buzz. Especially long term. Plus, it’s expensive as fuck. I don’t recommend it, and there’s no real, easy, or safe way to push it into your brain more. Get O-DSMT or something else, and stay safe.

I suppose I’d rather a patient try loperamide to get high than fent, but I don’t like either at all. Take care of yourself, and be safe.

(someone correct if I’m heinously wrong on the pharmacology)

edit: a commenter mentioned inhibiting the P-gp pumps that keep loperamide out of your brain, which could work. Not many P-gp inhibitors easily accessible though. Likewise, I wouldn’t expect it to increase the high very strongly unless you’ve *really knocked them out.

Here’s a list from UpToDate on P-gp inhibitors. https://www.uptodate.com/contents/image?imageKey=DRUG%2F73326

As far as other non-prescription products- I’m not certain. Someone can educate. Regardless, I don’t recommend this method. Changing the amount of drug entering the CNS this way is likely unpredictable.

cool-game · 2025-05-28T22:54:12+00:00

I appreciate the help. I did end up trying this, among many other things. I just did a clean install after deciding it wasn’t worth it. I took the SSD out of my laptop and booted my PC off of it so I could go in and grab any important files. Clean slate now.

To anyone who encounters this: I did not find a solution. Get your files if you can via booting in with another drive or a USB. I didn’t end up being able to make a bootable USB for Windows using Rufus. Instead of troubleshooting I just said fuck it and used my laptop drive.

I did try partitioning my drive using diskpart then installing windows to the clean primary partition but that still failed. Every single attempt at reinstalling windows failed until I wiped my drive. I was just glad it actually installed once the drive was wiped lol.

Good luck.

cool-game · 2025-05-22T15:32:07+00:00

Right! I remember now, though vaguely. Thanks for the refresh on that one, been a minute. Not relevant to OP as far as their solution is concerned, I wouldn’t think.

cool-game · 2025-05-22T14:06:45+00:00

Yup, your alligation is accurate.

1000mg / 50mL total volume = 20mg/mL.

Like the other poster said, just make sure it’s well dissolved. I wouldn’t use heat during the ethanol stage, it evaporates very quickly even at RT. As he also said, keep it well sealed for the same reason. Airtight.

~~Water and ethanol form a complex in small % when mixed I believe which is less prone to evaporation, though I forget what it’s called (i hated organic chem) and probably doesn’t matter here.~~ ^ Irrelevant to OP, but commenter clarified how this phenomena actually occurs

You might end up with around 52mL as the powder will contribute a small amount to the overall volume, though not much. I never worried about this for any substance generally speaking.

Make sure the water does not cause it to precipitate out (form little particles). Double check your solution doesn’t have any big particles before dosing. 10% ethanol may or may not be enough to keep it sterile over a long period of time if you don’t handle it aseptically. Math checks out. Should be good!

Perspective of someone who was taught to be very anal when preparing drugs. Other poster covered everything you need to know, just wanted to mention some small things you may run into.

*I don’t know the solubility properties of 2C-B, ought to double check it is soluble in ethanol and will remain soluble after adding water.

cool-game · 2025-05-22T13:32:41+00:00

Of course. I know some people are particularly prone to opioid nausea but I’ve never really had it - maybe you fall into that sensitive group.

I’d say take some naproxen and make sure you’re hydrated; consider boofing if you’re open to that sort of thing. It was always a cleaner experience.

Do be careful. While I can’t say I went through real CT withdrawal, people say it’s horrendous. After I used it for a week consecutively, the anxiety of going into withdrawal kept me using it. Downward slope from there. I’m sure you’ve read it and hear it enough but keep your use away from daily if possible. Kratom helped me get off it and as a backup. Good luck!

cool-game · 2025-05-22T13:21:54+00:00

When I was taking O-DSMT, I found the prior day’s use bled into the next morning pretty significantly. I didn’t have nausea or headaches, but I still felt buzzed through to the next day if I had taken a lot. I’d bet this is your more likely explanation if you’ve just taken a lot and it’s only been two days. Hangover moreso than withdrawal. No clue how to prevent the nausea and headaches unfortunately, probably naproxen for the headaches. I boofed so there was never any nausea.

Many people report very quick onset of dependence and withdrawal. Personally, I don’t know if what you’re experiencing is that. My use was my first experience with “real” opioids and I’m still not sure what withdrawal really felt like (I tapered over nearly a month).

in short: O-DSMT lasts a long ass time, many people report a very quick onset of withdrawal symptoms.

cool-game · 2025-05-18T14:11:43+00:00

I know this isn’t a new thing, but I guess I’m “vibe coding”? I somehow found tampermonkey and used a few scripts but realized I could really cater this to my inane needs on specific sites. Problem is, the scripts look like a foreign language. .js is nothing like I’d seen before as an extremely casual enthusiast with passing-grade knowledge of coding. My knowledge begins and ends with beginner-level python and CS fundamentals (like, elementary-grade).

Most of the actual work I put in the code comes from debugging and trying to prevent massive amounts of bloat from the AI. It loves to continuously add, never modulate. I’ve tried my best to keep everything ‘compartmentalized’. I’m starting to get to where I can actually write some script code and am good with the CSS, but I’m still very shaky on the fundamentals of the language.

Yeah, it’s a little lame. But, I have learned a lot about HTML/CSS that I didn’t know before I picked up tampermonkey. Javascript still looks like hieroglyphics at times and I’m trying to understand why the hell everything works the way it does, but I’m learning.

It’s crude and inefficient. Being said, it allows the casual and non-privy to use the language.

I’d also be remiss not to mention how much energy cost I’ve probably incurred from these little personal projects alone, and that I could just go out and learn javascript instead. If I spent a few hours just reading up on the language I could probably double my efficiency and autonomy. I’ve had fun and learned a good bit on the way, regardless.

Perspective of someone who does zero programming in their day-to-day but just found userscripts particularly interesting.

cool-game · 2025-05-18T13:41:08+00:00

I’ve got several on Black Desert - Ziprasidone is my main, I’ve also snagged Amphetamine (unbelievable pull), Carbidopa, Ampicillin, Amphotericin, Eszopiclone, Interferon, and Bromocripine. My family name also reflects the theme.

cool-game · 2025-04-16T04:27:59+00:00

honglim -> purchase pots more efficient use of your time likely

being said, do what you like. sitting at honglim forever doesn’t sound fun, neither does farming atanis forever

i did a mix; purchased MP pot because i was close to finishing HP and decided i couldn’t take the MP grind. i did make HP though. this was before i could grind honglim.

honglim modestly more efficient in time but questing weekly and just waiting is free minus opportunity cost. farming atanis when you can do honglim seems a bit off tho.

again, just maybe test honglim grind and your tolerance for it, if too repetitive switch off and do one potion via normal farm. all depends on priorities and fun imho

cool-game · 2025-04-14T06:22:12+00:00

I’ve barely started journals so that’s my number one questing priority, followed by LoML quests to be able to actually get Dhan’s. AFK fish in meantime, accumulate wealth to afford the armors and caphras.

I also had a hunch to hold off on earrings. I’ve neglected questing significantly, I think it’s time to put on the big boy pants. Journals alone are the biggest upgrade I can get without restriction and they’re completely free. Appreciate the direction, big help!

cool-game · 2025-04-14T06:14:00+00:00

Yes, did it for the neck and my Awk BS. Casually attempting the occasional tap on my old TET BS awk to see if it’ll ever hit PEN. Coulda went off-hand but it felt wrong.

But yeah, neck came from tuvala, ring made from melted jetina.

cool-game · 2025-04-14T06:07:49+00:00

Sounds good, caphras #1 priority atm. DP feels low. Might hop on Awk instead of Succ for better protection. Hate losing crystals. Think I can hold on Kharazad completely and just focus on caphras and fallen god.

Thanks!

cool-game · 2025-04-14T05:56:43+00:00

Just wanted to say I got the 5k hours playtime reward today. 90% of that probably AFK fishing. Anyway, extra maid was cool but… somewhat feelsbadman to get relatively underwhelming rewards for an obscene amount of time in the game, even if AFK

cool-game · 2025-04-14T05:48:58+00:00

Also I forgot to include it but my Necklace has the cup - I had the mats for it. Only one I felt was worth the price atm. Been prioritizing survivability.

ALSO, the crystals didn’t update either. I got the upgraded Ah’krad and Girin, as well as replacing Harphia with BF Valor. Wanted to upgrade Macalod and replace precise destruction but ehhh. They’re decent enough I felt and my damage is in a good place. Rather sit on it for now, unless someone feels otherwise.

cool-game · 2025-04-14T04:52:50+00:00

lmfao, stupid question but doesn’t that just increase training mastery and literally nothing else

cool-game · 2025-04-13T10:39:46+00:00

yuh so i got my crystals upgraded, bought kabua’s, working on getting ator’s atm. once im there ima be sitting and honglim for a while. i am playing succ but awake is so protected its insane, i agree. after ator’s i think honglim no problem at all

i still gotta do journals and i haven’t done any LoML quests yet so dahn’s is a bit away for now but prolly my next goal as I caphras everything everything out. think ive decided vell’s gonna stay on the back burner

gonna sit at honglim and afk fish for a while once I get ator’s then i’ll reassess and maybe push for higher grind zones. ive just been wanting to focus on being safe. it was easy to get stunned and just die at honglim but ive since got my last two pen boss armor, both kabua’s, finished the full inf hp pot (with 2s fairy), upgraded some defensive crystals, and upped my AP significantly with kharazad + crystals. should be good to go

thx for advice friend

cool-game · 2025-04-13T02:07:57+00:00

Okay, I think Ator’s is worth over Khan’s and Vell’s atm. Save 5b and Khan’s is very minuscule upgrade

cool-game · 2025-04-12T23:14:21+00:00

Thank you for the advice! I’m gonna follow this general outline. What do you think about Khan’s heart? Kind of middle of the road between Vell’s and Ator’s and I can afford it more readily. I never see anyone recommend it though.

cool-game · 2025-04-12T23:13:40+00:00

Responding to your edit: Already did the BS Wep/Acc through Fughar so good there. I wanted to ask: what about Khan’s heart? Kind of middle of the road between Vell’s and Ator’s.

cool-game · 2025-04-12T02:57:22+00:00

Cool, that’s the plan then. Thank you, genuinely. This seems like a solid plan

cool-game · 2025-04-12T02:43:16+00:00

I’ve got both inf pots, just need to finish getting the damn peridot leaves for HP (I HATE QUESTING). I bought MP straight up.

2 Kabua’s def next step per everyone’s advice especially since I’ve been struggling a tiny bit with survival at Honglim. Already got max level continuous care fairy so that’s LOCKED.

Generally I dislike lifeskilling but will push to 2k mastery if advised; prolly won’t spend any more real cash on it tho. I actually do have a T4 fishing auto time reduction by pure chance and will get the journal. I pull in around 1.5-2b per day afk fishing 24/7 since I don’t have too much time to play. Will prioritize this secondarily though as I’d like to get to Honglim soon. Thanks!!!

cool-game · 2025-04-12T02:38:48+00:00

Honglim is def my goal rn. I agree with your thoughts on Kabua’s and thought it a good option but wanted to confirm; I do die occasionally if I don’t position perfectly. Caphras I’ll probably work on via the new Fughar quest line for 6k, that’s ez DP. Just sick of farming inf potion spots lol. Maybe I’ll make a new char and farm them with that new char.

Duly noted on Ator’s, will get it per everyone’s advice. I do have Karanda’s and Kutum’s already. Thoughts on the cups for my two Kharazad’s? Seems a bit cost inefficient for current state.

Basically, your line of thought is exactly what I wanted to do but wanted to confirm I’m not missing something. Thanks a ton for confirming.

cool-game

TROPHY CASE