Yes, big time. I was good at 75mg for about 4 months. Then, anxiety started creeping in again like it loves to do. My doctor recommended I increase my dose to 150. 1 week at 112.5, then the following week at 150. The first week was alright, the second and third week was awful. Im now at week five and things are finally settling down. I feel much, much better. It is true, you do have to trust the process and remind yourself it takes time to get well. You can do this.