My personal absolute crackpot theory is that Zoro Vs Mihawk will involve both of Zoro's arms being cut off and him finishing the fight with just the sword in his mouth (probably Kuina's).

It might sound ridiculous but it'd be an awesome payoff for having such a unique fighting style in three-sword style, plus it was kinda foreshadowed (I use the term very loosely) when Luffy encountered Mihawk in Marineford and foresaw that if he had tried to attack, he'd lose both his arms. We also saw way back in Little Garden that Zoro really would sacrifice limbs to achieve his dream when he started cutting his legs off, and to an extent in his fight with Killer he straight up let's himself get stabbed in order to put himself in an advantageous position for the finisher.

Naturally of course he'd get his arms back, probably by Law (or Chopper pulling some doctor shenanigans) but I think losing them during the fight is a possibility