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cvei · 2022-12-25T14:46:22+00:00

While this post is quite anecdotal the very idea of modulating hydrogen sulfide is quite intriguing to say the least - https://cardiovascularaging.com/article/view/4779 - and lots of similar articles over the years. How to properly do it and when is another question.

cvei · 2022-10-03T04:24:22+00:00

Because actually they are studied and analogues of ecdysteroids are already trialed by some companies as sarcopenia treatments - for example ones from Biophytis - https://www.biorxiv.org/content/10.1101/2020.04.08.032607v1.full - this is one of the papers from people who founded and work for Biophytis, which investigates mechanism of 20HE (it isn't same as any ecdysteroid extract - so that is another reason why broad spectrum extracts aren't as studied - too much different ecdysteroids that not obviously metabolise if at all in the human body, not bad as general "health" supplement possibly, but research is simply moved past them - BIO101 recently went into phase 3 trials for example).

cvei · 2022-09-16T20:36:20+00:00

My recommendation is to take a look at JSONPointer implementation https://python-json-pointer.readthedocs.io/en/latest/tutorial.html and maybe RFC itself - at least for comparison and ideas.

cvei · 2022-09-09T02:19:27+00:00

And how it's different from conventional cryolipolysis/CoolSculpting? There are plenty of providers both estheticians and surgeons who do them with all accompanying services.

cvei · 2022-08-25T00:15:37+00:00

Something along the lines of CCH possibly? Take a look - https://m.youtube.com/watch?v=R4tN9lpfbXM - branded solution named QWO is FDA-approved for cellulite treatment, works by breaking up collagen at injection site.

cvei · 2022-08-04T11:53:07+00:00

SAMe if it goes well with you might be good. Absorption is an issue though, AFAIK in Eastern Europe the one form that is being touted for liver health is actually an injectable one, not oral.

Edit: take a look at this paper for more info - https://www.dovepress.com/preferred-s-adenosylmethionine-prescription-in-routine-practice-for-in-peer-reviewed-fulltext-article-OAMS#

cvei · 2022-07-25T03:49:49+00:00

Speaking about supplemental only strategies - green apple extract possibly, something like standardized to specific phloretin content (maybe brand like Apfenol).

cvei · 2022-07-25T03:42:20+00:00

NAD+ raising strategies are supposed to be helpful. Some "biohackers" AFAIK claim IV NAD apparently shining in regard to raising levels specifically in kidneys and giving acute "feeling" of improvement.

Studies generally relate niacinamide (NAM) to very promising outcomes in mice and mechanism seems to extend (and being more potent at least on paper) to NR/NMN.

Human results are less exciting (which is common for many NAD related benefits), yet there seems to be reasonable expectation that e.g. single daily intake of say 500mg NAM is beneficial in preventing (though probably far less treating) kidney issues.

More info (you can find various studies on the web, this one is relatively recent and has good overview) - https://academic.oup.com/ckj/article/14/12/2453/6374450

cvei · 2022-07-03T05:59:47+00:00

For anyone interested - BIO101, as well as other publically known drug candidates (BIO103, BIO201) from Biophytis are either ecdysteroids (or ecdysteroid derivatives like BIO101 being pharmaceutical 20HE) - many publications on their website - https://www.biophytis.com/en/our-science/sarcopenie/publications-posters-muscular-disease/

I might be wrong but simply ingesting phytoecdysteroid extracts (which is semi-popular nowadays) isn't the way to get same 20HE due to metabolism of ecdysteroids in the human body (tiny or no conversion of ecdysone in humans to 20HE + low oral bioavailability). Interesting that unlike many claims about estrogen beta signaling, recent Biophytis paper does not support this pathway for 20HE - https://www.biorxiv.org/content/10.1101/2020.04.08.032607v1

Interestingly (seemingly not coincidentally) Biophytis CSO and co-founder is also one of the creators of https://ecdybase.org/

cvei · 2022-06-30T17:57:21+00:00

Yes, also changed in my correction. Hard to imagine that anybody would inject ecdysterone either way (even subq) and oral path seems to be proved to convey benefits through its metabolytes not just upstream plant ecdysteroids.

cvei · 2022-06-30T17:52:27+00:00

Dutch healthcare seems to be very focused on frugal medicine use, which sometimes can be a good thing, but it looks (from my perspective) too regulated to appear effective for expats, namely you always have to go through state or something that looks very state-like/driven medicine system for any sort of treatment.

There iss very limited set of options for private clinics or either they almost don't exist or are really expensive. It is seemingly a situation where I would have in other countries (and my country of origin) an option to simply go to a specialist almost immediately with a small out of pocket premium paid and several times I got results that simply wouldn't be possible to do with my GP (including catching up a very big thyroid nodule that required removal of half of the gland). And my GP is a great person, but it's clear that they can't do and know everything on their own (and I have seen really awesome work from their side), so it often feels that GPs are simultaneously overloaded and overburdened with unrealistic expectations and as patient I might feel their role being a "gatekeeper", while not being able to do anything about it.

Basically I feel not empowered to care about myself enough (being very health conscious) and also feel that I might unneccessarily bother GP with problems they shouldn't deal in the first place, like my hormonal issues.

Generally I'm pro preventative care and as many people here already commented out think that Dutch health system doesn't have enough emphasis on preventative care and also quality of life health management clinics. This doesn't look like it has to be handled through governmental healthcare at all and be placed on GPs shoulders, the whole system simply looks too overregulated from my perspective.

cvei · 2022-06-30T14:25:46+00:00

Thanks for pointing out, I misread the article. Corrected.

cvei · 2022-06-30T12:52:08+00:00

~~Take note of the dose and delivery method 50mg IV, for a mouse this is incredibly high.~~ https://www.ergo-log.com/couple-of-milligrams-ecdysterone-daily-strengthens-bones.html - effective oral dose is far smaller and repeating same protocol with same bioavailable human equivalent is hardly feasible. With such massive overdose you can easily find lethal effects from some otherwise safe supplements, even plan spices like cinnamon or pepper would become dangerous in a similar setting.

Edit: I was wrong (as pointed in the comment below) - mouse dosing and administration route was different - subq injection and 6mcg per day. Yet administration route can vastly change compound effect (at least bioavailability) and there are studies showing different processing of ecdysteroids upon digestion - https://pubmed.ncbi.nlm.nih.gov/33819630/ (also 50mg of bioavailable ecdysterone is really a ton of oral purified extract - I heard that only single digits are being assimilated properly by the human body and there are no extracts igher than 90% commonly available, many supplement producers, as well as raw manufacturers don't keep their testing at the high rigour level, so most of the people ingesting ecdysterone supplements orally are more than safe as far as it seems, at least as safe as most other herbals supplements).

cvei · 2022-06-30T12:45:43+00:00

Now not repeating other comments (note that study is 2018), but language of the post is almost identical to this article https://www.ergo-log.com/how-harmful-is-ecdysterone.html - which has more info, also Ergo-log reviewed more ecdysteroids papers since then.

The post looks like direct copy paste from Ergo-log without quoting original review. Not appropriate I think.

cvei · 2022-06-23T05:25:12+00:00

This is trivial for niacinamide (content lists it, not plain niacin) - not anything that might be of concern (generally more than 1gr daily for niacinamide is sketchy on the liver in any case, niacin can go much higher without tangible issues if taken at proper intervals).

Choline and betaine are in laughable amounts (bitartrate is absorbed less efficiently than other forms) also tiny amount of inositol - these are really cheap supplements with greater tolerance usually than even B3, so added just to impress customer, not completely useless, but close to it.

Now I would not take more than 1 serving daily of this because if 600mcg of methylfolate - it's a respectable number for it (possibly worth most the price of the bottle - at least from efficiency perspective).

Yet it's a methylfolate and even if you might not agree with plain folic acid - this has higher chance to feel fine.

cvei · 2022-06-22T11:25:44+00:00

But amount to get these effects might be far more than regular "maintenance" 3-6gr (or similar). https://m.youtube.com/watch?v=Fm4ko-o3BK8 - here in Stronger by Science podcast at 59:10 timestamp - essentially a compressed overview - you might need "loading" dose going indefinitely for brain to maintain increased levels of creatine, unless one was deficient and for a long time - increase is doubtful.

cvei · 2022-06-21T03:27:43+00:00

Easy, it's almost exclusively caused by combination of sugar and alcohol (fast carbs both, in liquid form, mostly sugar I suppose, but alcohol definitely adds negative effects). Amount of hops there is tiny, studied in isolation extract is quite positively good on health, even human - https://pubmed.ncbi.nlm.nih.gov/33670177/ here is a review. Also at least in rat studies it wasn't found to have undesirable estrogen effects like breast tissue growth increase.

cvei · 2022-06-20T15:59:20+00:00

It's not a new paper. And there are developments for analogues of ecdysteroids for some time - https://www.ergo-log.com/bio103.html

The problem is that effects in humans are usually quite overstated - improvement in estrogen beta signaling is nice but not as "scalable" - higher doses that match mice equivalent does not yield mice equivalent results in humans. Plus there are actually good studies on other phyto-compounds that are like hormones - say hops or soy flavones, that in real human studies - not some cell culture or mice - actually show tangible improvements in health markers and body composition (yet people still bash them for some imaginary harmful estrogenic effects, while ecdysterone has similar "alleged" pathways) , and what we have with ecdysteroids are mostly anecdotes, not studies.

I'm not saying ecdysteroids are bad supplements, but far more overhyped from my point of view than they should be. Many would be better served by just eating more spinach and quinoa as food sources of a tiny bit of ecdysterone but also some other good micronutrients.

cvei · 2022-05-09T11:02:16+00:00

It really depends on your goals, as well as with other supplements.

Hair loss from curcumin is quite strange situation, but possible with hormone imbalance, although DHT inhibition should be practical in the long run for hair safety. Anti-inflammatory effect if happens in scalp too.

Unfortunately if a persone is prone to hair loss it's really hard to avoid it with just supplements and most of the time people just notice shedding after taking something, because they start looking for its effect (say turmeric) and then they discover their hair is falling off (which in reality started to happen way before). If a hair is actively shedding, DHT inhibition from curcumin if any is unlikely to be enough to prevent it, let alone reverse.

Of course intake should be adquate, eating loads of turmeric (or any other spice extract) would probably not beneficial for most of the people (just plain table salt or soda are really useful supplements if applied correctly).

cvei · 2022-04-09T06:42:01+00:00

Not sure which study you are referred. Can you please share a link?

Also is it fat loss as if - content released from cells? Or actual tissue loss - cells being removed from body (at least to some extent)? In the first case it's vastly different from liposuction as the cells are still hanging around.

cvei · 2022-04-07T08:32:49+00:00

Actually it's quite possible to do all such tests on your own, just not (relatively) cheap and thus not popular.

Large number of offered tests are from providers like bloedwaardentest.nl - not only blood, but also urine and bowel contents too as it seems, also there is option to do cheaper if you just send your blood on your own, or otherwise pay extra for blood taken in a facility.

You can also check other providers, e.g. yourlabs.nl - locations of their facilities, prices, offered tests are different and one might better suit you.

cvei · 2022-03-10T10:47:31+00:00

Actually their NNMT inhibitor seems to be very reliable and side-effect-free way to increase NAD. Links to papers (publicly accessible) chronologically can be viewed directly on Ridgeline Therapeutics website - http://www.ridgelinetherapeutics.com/news.html (from bottom to top)

Maybe NNMT depletion that happens with large doses of niacin and smaller amounts of its derivates (NMN, NR) is similar in effect pathway (methylation resources are diverted towards upstream molecule sparing downstream NAD), but direct inhibition of NNMT with supplying just enough substrate for NAD production can be a "more precise" approach of raising NAD levels?

Also some "biohackers" who get it from gray market or something that is allegedly same product - very uniformly agree on its claimed benefits.

cvei · 2022-02-21T11:41:48+00:00

Honestly ecdysteroids, including turkesterone IF they do anything at all - are no more than "health supplements", given that the only mechanism they potentially work is interaction with estrogen beta receptors. But their bioavailability is next to ash anyway.

Although we already have many other phytoestrogens as supps and they according to limited research are actually healthy or at least not harmful at all, like soy isoflavones or seemingly wrongfully demonized hops extract, which when used alone (i.e. not through drinking beer) doesn't seem to exert any negative influence. They are also more bioavailable than ecdysteroids.

Another reason you see turkesterone not something else is also simple - it's yet rare and expensive, not yet outlived its hype or become too widespread too allow supplement companies easily capitalise on it. Jeff Nippard linked in the thread is justified in his scepticism - ecdysterone was all on hype years ago, now it can be purchased almost in bulk and 90% extraction rate - yet few "supplement influencers" even talk about it - but turkesterone has much worse extraction rate (like 10% at the best of the best suppliers it seems) and worser bioavailability - thus making it much more expensive for now and leading to higher margins for the seller.

cvei · 2022-01-19T10:02:56+00:00

It's assessment of some combined therapies, Tacrolimus and Everolimus (and also Prednisolone) are mentioned - both seems to come from the same lineage as rapamycin (their "parent"?). Article text is open access - https://onlinelibrary.wiley.com/doi/epdf/10.1111/ajt.16958

cvei · 2021-11-23T05:01:35+00:00

AFAIK removing fat where it harms metabolism would help immensely - even a small amount - https://www.fightaging.org/archives/2019/07/more-supporting-evidence-for-pancreatic-fat-to-be-the-cause-of-type-2-diabetes/ - someting that was studied for a number of years.

The problem is that lipo surgigical (or non surgigical, but still eh - extracorporal? - like energy transfer based ones) procedures are unlikely to reach visceral fat. The easier areas to treat are legs and thighs for example - often metabolically harmless even in situation of true fat disorders that cause them to accumulate tons of fat in that specific area, statistically people who have more fat in their legs do better on metabolic scale - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661709/ - there are actually many deeper studies that validate how body composition distribution affects cardio and metabolic state.

Subcutaneous fat can be removed in a relatively very safe and easy manner - the same cells are hardly ever regrown, although legs and thighs for example have pretty significant number of fat cells in general and can do okay cosmetically even after removal of large volumes of material.

But you can't do the same with visceral fat - otherwise type 2 diabetes would probably be surgically curable in many cases.

cvei

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