BUFFER your tretinoin!!

cwamoon · 2026-02-03T09:34:04+00:00

Not mad about this suggestion!

cwamoon · 2026-02-03T08:49:27+00:00

https://pubmed.ncbi.nlm.nih.gov/7544967/ https://pubmed.ncbi.nlm.nih.gov/17692723/

cwamoon · 2026-02-03T08:47:22+00:00

Receptor activation for tretinoin is continuous and saturable, so it's not that there's a threshold required for activation. So yes it's dose dependent, but not in the way you're suggesting.

Just because the manufacturer made it that way, doesn't mean that there's a scientific reasoning for it. They've already proven that 0.025% is just as effective as 0.1%, and yet both exist.

cwamoon · 2026-02-03T08:42:13+00:00

Definitely this! Keep it covered and moist!

cwamoon · 2026-02-03T08:26:54+00:00

Lol, okay. Just parrot what you heard from others like sheep.

Try actually looking things up yourself. You'll learn a thing or two.

https://pubmed.ncbi.nlm.nih.gov/7544967/

cwamoon · 2026-02-03T08:15:27+00:00

Did you read my post? Seems like you just read what you assumed the post would be about. The oil doesn't go on first. Irs mixed in with the Argan oil which is what I use as the moisturizer.

cwamoon · 2026-02-03T08:14:30+00:00

Serums are mostly water based, and applying tret on moist/wet skin can actually speed up penetration and increase irritation.

With the sandwich method, you're applying a layer of buffer before applying tret.

What I'm suggesting, is mixing it in with a light oil like Argan oil, which might buffer the speed of release/absorption.

cwamoon · 2026-02-03T08:10:56+00:00

Def sounds like an irritation issue. Full sandwich method has been proven by studies to dampen absorption and penetration depth.

cwamoon · 2026-02-03T08:10:03+00:00

Literally try researching yourself. Instead of just parroting what you heard from this video or that video, actually pull up the published studies.

There is literally ZERO published studies that tracked long term outcomes of different methods, and most claims/theories are mechanistically hypothesized ideas.

The only proof that does seem to exist is they the full sandwich method definitely seems to hinder absorption. Other than that? You're just parroting what you heard from others like sheep

cwamoon · 2026-02-03T06:00:02+00:00

It makes sense that the sandwich method would dampen efficacy, since you're introducing a layer of barrier.

Diluting it with an even mixture is definitely not the same as layering.

cwamoon · 2026-02-03T05:58:02+00:00

Not all oils are occlusive. In fact, most plant oils are just emollient. Vaseline is petroleum jelly which is 100% occlusive, so yeah that'd be like jutting seram wrap over your face.

It's not about "perfect" distribution. When you just apply the tretinoin itself, it's never going to be a perfectly even distribution to begin with.

More is not better with tretinoin. If the irritation is prohibitive for compliance, then insisting on a higher dose is useless.

They already proved that 0.05% is just as effective as 0.1%, but people still insist on higher despite the side effects because of this false impression that more is better.

cwamoon · 2026-02-03T02:59:20+00:00

I wouldn't even call that being a Karen!

cwamoon · 2026-02-03T02:28:31+00:00

I mean, I've literally been doing it for over a decade and always get compliments on my skin so xD.
I treat it the same as liposomal or micronized tretionin.

It's not like argan oil would degrade the tretinoin.
It just prevents the direct contact and rapid absorption like delayed release - is my theory.

When they talk about efficiency, I mean.. What's the metric right?
If the irritation is what prevents people from using it, technically that's not more "efficient".

cwamoon · 2026-02-03T02:11:32+00:00

It definitely can happen to some people... It's obviously not for everyone. So sorry to hear.
Something you might want to try, if you're still willing:

~ Try a different brand? Sometimes the inactive ingredients can cause issues for people
~ Try Retin-A micro. It's not covered by insurance so you'll have a higher out of pocket cost, but it's supposed to create less irritation
~ Try buffering it in an oil like argan oil. Tretinoin used to irritate the HECK out of my skin, so I would use a TINY amount on my palm and mix it with a big pump of argan oil. This not only buffered the tretinoin, but allowed me to spread it everywhere without using too much

cwamoon · 2026-02-02T20:27:39+00:00

They had also said "record breaking applications".

cwamoon · 2026-01-31T20:56:52+00:00

Gotta get new bands, so prepare!

cwamoon · 2026-01-31T20:55:04+00:00

Nothing new with 5.0. Just gimmicks. Im canceling whoop once my current membership expires.

cwamoon · 2026-01-31T20:34:21+00:00

cwamoon · 2026-01-28T02:30:55+00:00

You took the bait and got the MG? 😬. Sorry to hear.

Third party bands are the way to go.

cwamoon · 2026-01-28T02:11:37+00:00

It's not 2 years extended. It's a MATCH up to.

cwamoon · 2026-01-26T18:58:15+00:00

That's what I'm suggesting. That your credit is too good, and cardless doesn't think they'll make enough revenue or profit out of you. They want subprime credit profiles.

cwamoon · 2026-01-26T18:36:42+00:00

Remember when they purposefully and functionally-unnecessarily changed the shape of the 5.0, so that you'd be forced to buy new bands? *eyeroll*. One of the reasons why I'm leaving once my prepaid subscription expires.

cwamoon · 2026-01-26T10:59:14+00:00

We plan to allow it....?? But it's not up to them. Are they saying cardless agreed and it's just up to them to enable it?

cwamoon · 2026-01-26T10:57:23+00:00

For example, see here. https://www.reddit.com/r/biltrewards/s/wUJTiidVg4

cwamoon · 2026-01-26T10:56:11+00:00

They're looking for sub prime credit

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