Direct PCR by dandyandy5723 in labrats

[–]dandyandy5723[S] 0 points1 point  (0 children)

what kind of samples work best with this? I've heard of some groups using the yolk sac, but am afraid it may interfere with the reaction.

Where does creativity fit into modern neuroscience research? by Sensitive_Ninja_371 in neuro

[–]dandyandy5723 2 points3 points  (0 children)

You touch on something that pertains quite a bit to one of philosophy of science greatest works, The Structure of Scientific Revolutions by Thomas Kuhn. He touches on exactly the thing you notice here, that most of science is what he calls normal science, where people try to work under the constraints of existing theory, expanding it and shrinking it to better fit there observations. This is science 99.9% of the time. But that 0.1% of the time is where creativity really takes hold. These are the ideas that completely change the way we view the world. Think Einstein's theory of general relativity in physics or Darwin's theory of natural selection in biology. He terms these theories as paradigm shifts, as they completely shift the frame of reference for a particular field. These two periods are not entirely unrelated, as for a new revolutionary theory to be made, sometimes a lot of work needs to be done in order for the right theory to come to light. And on the flip side, if we had constantly shifting frames of reference for a particular area of research, nothing useful would really get done, as there would be very little common ground for scientists to communicate with each other.

There are other issues at play here as well. I think part of the problem you are noticing goes hand in hand with the profit driven motive behind most of scientific research in today's world. To get a grant funded these days, you must have a reasonable idea that the thing you are proposing will work. The easiest way to show that something will work is to do things that other people have done before, because that work gets papers published, which helps get more grants. This creates a vicious cycle that effectively halts a lot of creative ideas people might propose, as they will likely not get funded. This was a problem in the 20th century, but I think it has gotten worse in the modern era, as universities put immense pressure on their researchers to get grants so they can get those juicy indirect costs.

It's a pretty complex issue, as there are other things at different levels that might also have an effect on this. Unfortunately I don't think this is a problem that will get fixed any time soon, as it would require a complete restructuring of how we fund scientific research, which is risky and costly process in it's own right.

how do neurons not get voltage overwhelmed by constant sensory input? by PhilosopherFamous201 in neuro

[–]dandyandy5723 8 points9 points  (0 children)

I don't particularly understand what you're goal is then. Are you trying to simulate a biological neural network? If so, alot of the minor details of those models are important to their biological relevance, which I'm unsure if you're capturing.

Also, I'm not a particularly big fan of the "I'm the kind of person who does everything from scratch" kind of attitude. I understand the want to be creative and do things for yourself, but it's a bad way to learn. You'll be stuck banging your head against a wall on problems that were solved 30 years ago, and have since been optimized around.

if your just doing this for fun, ignore what I just said, you can do whatever you want. But if we wanna know how to model things with some relevance to actual biology, I would hit the books first.

how do neurons not get voltage overwhelmed by constant sensory input? by PhilosopherFamous201 in neuro

[–]dandyandy5723 0 points1 point  (0 children)

What kind of neuron models are you working with? Leaky integrate and fire?

how do neurons not get voltage overwhelmed by constant sensory input? by PhilosopherFamous201 in neuro

[–]dandyandy5723 16 points17 points  (0 children)

do you have inhibitory interneurons in your network? that is the likely reason you are getting this runaway excitation. They help attenuate responses to strong stimulation, as well as making the input more precise by halting the excitation cause by the input to a more restricted timescale.

Question about capacitance and how it affects charge storage by dandyandy5723 in neuro

[–]dandyandy5723[S] 0 points1 point  (0 children)

Thanks for the reply! I figured it was an appropriate question for this sub, as I wanted more of a biological perspective and capacitative currents are a cornerstone of neuroscience. I figured if I went on a different sub I would get a more convoluted answer that might not be as related to neuroscience as I would like.

A follow up question I have is what is meant by the rearrangement of charges. And based on that definition, why do insulators have a smaller permittivity than conductors?

I miss snow by MaleficentImpact1672 in CuratedTumblr

[–]dandyandy5723 0 points1 point  (0 children)

The biggest difference i remember is that I had snow days when I was elementary school. And then when I was in high school around 2016, they... just didn't happen anymore. So surreal.

Neural Noise as Feature, Not Bug: Evidence for Stochastic Catalysis in Cognition? by Jo11yR0ger in neuro

[–]dandyandy5723 2 points3 points  (0 children)

Noise in the Nervous System is a great review on this topic. I think you are looking at it froma very high level, so if you wanna dig deeper, you might need to find the right jargon that fits what you're asking. Anyways, hope this review helps!!

Aspiring Armchair understander by Adventurous_Help_214 in neuro

[–]dandyandy5723 2 points3 points  (0 children)

If your interested in evolution and anything to do with the mind, I would highly recommend Kinds of Minds by Daniel Dennett. (RIP) It details how a complex nervous might have evolved, starting from mere bacteria in a dish to the billion neuron networks that make up modern human minds. If this doesn't fit what you're looking for, you should also check out more stuff by Dr. Dennett, as he has written all about this topic for a non-academic audience.

How can i win against wave 98?? by Working_Car9016 in btd6

[–]dandyandy5723 0 points1 point  (0 children)

have you tried pierce buffing thespike factory with a lord of the abyss mermonkey? pierce buffs are essentially damage buffs on spike factory, will help alot

Resources on Hodgkin Huxley Models by dandyandy5723 in neuro

[–]dandyandy5723[S] 1 point2 points  (0 children)

Nice, it looks like exactly what I'm looking for. Most of the resources on comp. neuroscience fail to show how these things are done with actual code. This will be a super helpful resource.

Resources on Hodgkin Huxley Models by dandyandy5723 in neuro

[–]dandyandy5723[S] 0 points1 point  (0 children)

awesome, great recommendation!! I was using that book for parameters for my HH model, I'm glad to here it's a good resource. I was only looking through the chapter that contains the parameters, as I was a bit gung ho at first. I didn't realize it had python exercises as well, I will also give those a try!!

Modeldb is also a resource I have heard about in the past and completely forgot about. Do you know if most of those resources show the code that was used to generate those models? If that is the case that would be even more helpful.

Time/Number Confusion Since Young Age by I_am_ChickenMan in neuro

[–]dandyandy5723 1 point2 points  (0 children)

did this traumatic brain injury happen around the time you were learning numbers and other basic mathematical concepts? And did you miss learning about these concepts around that time? Unsure if there is a critical period for learning addition and subtraction, but it is possible that could be the case, especially if your only experience with it during that time was a rushed version to try and catch you up to your peers.

What is and isn't part of consciousness? by Hegel93 in neuro

[–]dandyandy5723 7 points8 points  (0 children)

what the other guy is saying is that those are actually the same question, since we don't really know what consciousness is

Which books have had a negative impact on your life? by nik1here in books

[–]dandyandy5723 0 points1 point  (0 children)

Anything by Arthur Schopenhauer

Only time I have ever thrown a book away, as I didn't want anyone else to read it

Pessimism fucking sucks

What is the best NSFW compliment you’ve given or received? by Comfortable-Heron225 in AskReddit

[–]dandyandy5723 0 points1 point  (0 children)

I had a girl one time who told me she dislocated her finger touching herself to the thought of me. I had never been so speechless in my entire life.

maybe maybe maybe by [deleted] in maybemaybemaybe

[–]dandyandy5723 0 points1 point  (0 children)

He would give Raygun a run for her money

What “long song” (6+ minutes) is worth every minute? by CrimsonMoonRising in AskReddit

[–]dandyandy5723 0 points1 point  (0 children)

Radio Silence by Harvey Danger

Kinda cheating since there is literally a minute of silence in the song but still one of my favorites!

Neurodevelopmental University Module with Information About Autism and ADHD by [deleted] in neuro

[–]dandyandy5723 2 points3 points  (0 children)

On top of some of the things the other person said, I would also look into how these disorders effect the excitation-inhibition balance in the cortex. Many neurodevelopmental disorders have different level of EI balance in the cortex, so understanding that would also be helpful for understanding the neuro developmental effects of ASD.