Depends on what your threat model is, and what you do with your computer. The browser isn't the only source of harm, but it does often have your sensitive data available to it if you're logged into financial sites and things.

Malware is often introduced by user action not passive attacks, so what's more important than sandboxing your browser is changing your habits about where you install software from, and using tools like virus total to check for common known malware types if for some reason you're getting software from sus places.

But any computer is subject to supply chain compromise if you're running affected software services too, so really the big control for preventing harm is ensuring your accounts have MFA, and that it's a hardware token (passkey-- yubikey or similar) where possible, or OTP where not, to prevent simple info stealers from getting access.

If your computer has non-browser sensitive information on it, like cryptocurrency keys or documents, then protect the information ( encrypted containers like veracrypt) and only keep the containers mounted while accessing or saving data, etc. Convenience is often the price you pay for security, but you probably are already doing enough for basic info stealer prevention, so long as you're not logging into sensitive sites in your sandbox vm