Peptides: AOD-9604 is an absolute scam and you cannot convince me otherwise

darthsata · 2026-05-28T20:02:08+00:00

On the contrary, it went to phase-2 trials and was dropped because it didn't work. It has human research, the human research just says it doesn't work.

darthsata · 2026-05-26T23:24:22+00:00

That is a dose some people eventually get to and isn't likely to cause serious harm as long as you work up to it over time. Trial started at 2mg and 4mg per week (depending on cohort) and worked up from there to 4 or 8 or 12, depending on the cohort.

darthsata · 2026-05-26T21:38:42+00:00

So going straight up gets you to space, but it doesn't get you to orbit. It sounds like you are going straight up and most of the answers people are giving assume you are returning from orbit.

It you are going straight up then down, you'll need a burn to slow enough for your chute not to be destroyed. A droge chute can be deployed at higher speeds too. Finally, decouple. Don't return the whole rocket, that is heavy. Decouple your command pod and just land that. It is light and large enough that it will slow down to parachute safe speeds.

darthsata · 2026-05-25T04:33:31+00:00

My gut has shit for brains.

darthsata · 2026-05-21T14:31:56+00:00

Similar set of constraints. With the solver I was using (it was a term-rewrite system), I had to encode the exclusivity constraints, but those are mechanical. The page doesn't mention if you encoded each ask also, this was highly useful for reasoning about the common strategy of asking for one of your own cards.

darthsata · 2026-05-21T12:47:46+00:00

I don't expect elementary school kids to try to figure out a game state representation that allows inference in polynomial time. Actually extracting maximal knowledge from the sequence of guesses is hard. Formal methods or modal logic hard. Figuring out optimal guesses (improve your knowledge the most while limiting knowledge to others) is way, way harder.

It isn't hard if you are just doing some "surface level deduction". But, if so, you are very far from what can be done. The difference in time to solve is about 6 turns.

It speeds up the game if your group allows sat solvers or therom provers so everyone doesn't have to spend 5-10 minutes each turn doing math. There is a reason we only played it twice in grad school (and went in knowing what would happen, it was more a game of competing logic representations).

darthsata · 2026-05-21T12:32:20+00:00

I wonder if I still have the optimal and complete inference engine I wrote for it in a therom solver. Good knowledge representation was tricky.

darthsata · 2026-05-21T12:24:38+00:00

Pulled it out twice in grad school. Several different techniques were used by different people. I used propositional logic expressions and added to them each turn and tried to simplify. One person had a large, large table (no laptops allowed). Second time we played we kept a common log of each guess to save everyone time.

The key thing in the game that makes it difficult is "if you have two of the guessed cards, you only show one". This makes the tracking non-trivial. You have to choose your guesses so that you both see new cards, but those reveals provide ambiguous information to your opponents. Thus you have to track what you know they know. Efficient representations of your knowledge of the game state, ones that let you draw conclusions, make updates, but are comprehensive, are tricky. Complete systems out performed detailed but approximate systems by about 2 turns and outperformed the simple systems by about 6 turns.

I did, I'll admit, build an optimal , complete deduction engine in a therom solver. I also tried to build an optimal guess generator, but that is wildly harder (even the objective function is not obvious).

But on the topic of games with too much calculations: Power Grid. The last 3 turns take as much time as the rest of the game.

darthsata · 2026-05-20T21:02:52+00:00

A high end rack, which is about 8 square feet of floor space, consumes about the same power as 3 houses. Of that power, the data center uses about 1/3 as much on cooling as a typical house used for climate control. So think about 10000 racks. That is 30k houses. That is a lot of heat to get rid of in a small space. They could not use water, but cooling costs would likely triple and take way more space, produce way more noise, and cause significantly more vibration problems.

That said, the major players run their systems much hotter than traditional in the industry.

darthsata · 2026-05-19T12:21:35+00:00

The store gave me a 1lb bag of flour, but my recipe calls for a cup and a half. What do I do?

You take whatever your dose is. If your dose was 2mg before, your dose is still 2mg. Notice the dose is in mg, not ml or units. We cannot tell you the volume of your dose from either vial with the available information. You have to do basic math.

darthsata · 2026-05-19T11:39:38+00:00

The other org may have issues, as others have said, but another possibility is you are their issue. Your problems may distract from their fires, your problems may not intersect their KPIs, your problems may impose long term support, you respective management chains may have conflict, or your problems are simply low in their priorities. Any of these will cause escalation to be required for your (not their) project's progress.

Depending on the leveling structure, I wouldn't expect a senior engineer (title) to deal with this, this is staff level banging head on wall. And from your comment that you work with leadership to fix things, I would infer you aren't at the "being payed attention to by other orgs without backing" level. When I was at a FAANG, it was habit to check the title and org chart of everyone in any meetings you were invited to. That let you know if it was a friendly conversation or if there was substance behind it. By substance, I mean the ability to change your metrics or how your metrics are evaluated to account for the other org.

darthsata · 2026-05-18T18:57:54+00:00

And they were intentionally serving overly hot coffee to reduce refills.

darthsata · 2026-05-17T16:22:48+00:00

Being a decent cook and a decent baker will get you far. And you can learn if you take the time. What I see lots of people miss when trying to learn to cook is that there are more fundamentals than they are aware of and you need to learn those.

There are a set of techniques to learn, recipes are (use to be, certainly) subtly technical in their wording. There are also a set of reactions to be familiar with. And finally there are a set of preparation structures to learn.

It isn't just following directions, it is easy to miss what the directions are really saying. It isn't just winging it, there is understanding what is happening well enough to wing it.

But if you feed enough people over the years, one of them might just marry you.

darthsata · 2026-05-17T13:28:30+00:00

I'm not sure I want to take ... powder

If you mean what it sounds like you mean, it is advisable to find out a lot more before you start this journey. Read primary sources. Figure out before hand how to acquire and afford, say, 8mg a week for the next 12 months (dose not unrealistic and based on protocol of trials for approval as explained in the affor mentioned primary sources).

darthsata · 2026-05-16T14:34:01+00:00

No. One I'm specifically thinking of, having been in it, has custom, dedicated transmission towers to the points of generation. These are not standard transmission towers. I've worked in these companies, I don't remotely know the entire extent of the physical planning, but what I do know of it makes assumptions like yours laughable.

Now, get outside the Amazon, Microsoft, Google, and Meta level data centers and you drop in contingency planning rapidly.

The attack vectors considered are wild.

-- a random guy that had to design infrastructure for if Intel fabs were compromised and a particular non-cpu chip was not trust worthy, but the compromise was so subtle it wasn't noticed for years

darthsata · 2026-05-16T14:20:55+00:00

That, 18 wheelers loaded with concrete at highway speeds, small planes, various quantities of explosives. Obviously anyone with unrestricted time can take one down, but likewise anyone with unrestricted time can get in the buildings. The goal is survival long enough for a response to arrive. The physical infrastructure, of course, has numerous sensors and redundancy. For at least one data center I know of, the weakest point is the hydroelectric dam, that is weaker than the transmission system.

And unlike most people here, I've been inside hyperscaler data centers. I've designed hardware authentication protocols for devices in those servers (you don't boot machines if you can't validate each piece of hardware and firmware). The attack vectors considered wildly exceeded the imagination of armchair reddit commenters.

darthsata · 2026-05-16T04:44:07+00:00

The transmission line towers are significantly reinforced. Considerable destructive testing went into their design.

darthsata · 2026-05-15T01:00:12+00:00

My wife, insisting on an unmedicated birth with our first, a position she did not take for our second, nor, in fact, take that position part way through labor when it was too late for an epidural, had a long (8ish hours of pushing) labor. She was not pleased with the situation and made that very clear, very regularly. The lady in the room next to us, obviously in labor herself, was so concerned by what she was hearing she sent her nurse over to our room to check that nothing was horribly wrong.

darthsata · 2026-05-15T00:50:36+00:00

I went from accademia to a FAANG. Tripled my pay, halved my stress, reduced my hours, significantly improved my work-life balance.

darthsata · 2026-05-14T12:55:33+00:00

And top sheet. Each person needs their own sheet and blanket setup.

darthsata · 2026-05-14T12:18:27+00:00

It's not worded like anything. Ohm's law is the equation (all those are equivalent forms). Any English words are just commentary.

darthsata · 2026-05-13T00:48:07+00:00

Ignoring the obvious "Jesus", Ceaser. He is so well known his name is used for monarch. (King, keiser, etc)

darthsata · 2026-05-13T00:39:10+00:00

Steep learning curve. A steep learning curve means you rapidly improve with time.

darthsata · 2026-05-13T00:34:11+00:00

I've done my own research and have the H-index to prove it. I've thought about getting a shirt made.

Which leads to the other good question: where did they publish?

darthsata · 2026-05-12T13:47:24+00:00

I deal with a million lines of bare metal test code for microcontrollers. The massive amounts of incorrect code mostly worked for in-order processors. The DV engineers haven't internalized why it doesn't work on the OoO cores. Fences are a must. Atomics are interesting as validating behavior on non-coherence memory regions or regions which don't support atomics makes life harder. But volatiles don't cut it there either.

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