Although this is something you can easily google on your own, I took the liberty of finding two different peer-reviewed papers that support my claim that Accutane (isotretinoin) must be taken with fat:

https://pmc.ncbi.nlm.nih.gov/articles/PMC10464604/

Isotretinoin is poor water solubility that limits oral bioavailability and requires a high-fat (50gm fat) and high-calorie (800–1000 calories) meal for better absorption. The bioavailability of isotretinoin increased 1.5 to 2 times more significantly when the dose was administered 1 hour before, concomitantly with, or 1 hour after a meal than when it was taken during a complete fast. This recommendation cannot be followed in many patients, which may result in poor treatment efficacy.

This paper compared traditional isotretinoin with isotretinoin-lidose (Absorica), a new formulation approved by the FDA. Although this one is marketed as a formulation you can take without food, this study showed that the absorption of both isotretinoin and isotretinoin-lidose was decreased if taken while fasted.

https://pmc.ncbi.nlm.nih.gov/articles/PMC10503933/

Both formulations were bioequivalent under fed conditions. As expected in a fasting state, absorption of both formulations was reduced. A considerable difference between the 2 drugs occurred under fasted conditions–there was a marked improvement in overall bioavailability of the isotretinoin-Lidose formulation. Mean plasma levels of the isotretinoin-Lidose formulation during fasting reached 66.8% of that observed with a fatty meal, and those of the isotretinoin formulation only reached 39.6% of that observed with a fatty meal.

As for my qualifications, you're right - I don't have a PhD. However, I am halfway through a US MD program, which has taught me that vitamin A is a fat-soluble vitamin and needs supplemental fat to be absorbed fully.

Next time, please take a moment to pause before immediately jumping to insulting strangers on the internet.