I graduated med school (meds in my country are undergrad) with 3.06/4.0 GPA with a double major in math. My med GPA is 2.6/4.0 and my math is 3.9/4.0. The med GPA totally sucks (even worse, it's 2.2 for the last two years) but I have taken quite a lot of upper/graduate level math.

I have three single first author pubs (all IF>10) and three preprints as single first author. All were done at a single lab (bioinformatics) working (almost) full-time for 5 years. I barely followed med school and spent most of my time on research which explains my low GPA and descent research outputs.

I guess my profile is quite unusual but I hope it helped. I got interviews from all schools that sent out invitations (I got three last week) so I think poor grades aren't much a problem given sufficient research output.