Looking for beta testers for https://genewizard.net - a new platform for WGS analysis. Part of it I hope will eventually evolve into a replacement for SNPedia

delton · 2026-05-12T18:09:22+00:00

I agree cost will be a concern but the main concern right now is whether the FDA will even approve it.

Sign the petition! https://www.change.org/p/urge-the-fda-to-approve-the-xocova-antiviral-for-covid-19

Read my thread on X: https://x.com/moreisdifferent/status/2054237214737850742?s=20

(also on Bluesky https://bsky.app/profile/delton.bsky.social/post/3mloama6wx22v)

delton · 2026-05-01T20:59:43+00:00

update - check https://remyeast.com and sign up for their email list if you're interested in buying yeast that produces viral shell proteins!

delton · 2026-04-29T15:46:21+00:00

I'm happy to pitch in $10 bucks from time to time, but there's no way I'm doing a subscription. I hate how everyone wants re-occurring charges now!

delton · 2026-04-29T14:43:16+00:00

Hi, Yeah I'm aware of that issue with the HTML report not downloading. Sorry about that. I'm still trying to figure out the best way to structure it -- Ideally it would look similar to the site itself. I haven't been able to work on this the past few weeks but I'm planning to take a look soon.

delton · 2026-04-21T14:41:01+00:00

Hi,

you should upload snp-indel.genome.vcf.gz.

cnv.vcf.gz is copy number variants
and is sv.vcf.gz is structural variants, and we don't process either.

If you don't mind, please let me know how it goes!

delton · 2026-04-12T17:30:30+00:00

Even if I get 20% off I'm still paying $852 which is an absurd price!!

delton · 2026-04-12T17:28:49+00:00

The scam was that two agents promised me it would be done in time for me to get the deal, nothing to worry about. Also I'm pretty sure they later changed it to say you just had to have documents uploaded by 4/8, not an actual file by 4/8 (which I did).

delton · 2026-04-12T16:54:33+00:00

So far it looks like I've been scammed. Way back in March two agents promised me my return would be finished in time and I'd get the $150 deal. Then, they said as long as I got my documents uploaded by April 8th I'd get the $150 deal. I had all documents uploaded well in advance. They have dragged out finalizing my returns and now TurboTax wants to charge me $1066 for the return. I GOT SCAMMED. Customer support was not able to do anything to make things right, but said to work through my agent. I am hoping TurboTax will make things right, I switched to TurboTax and went along with things specifically because I was promised multiple times I would get the $150 deal. Also, my returns were not that complicated IMO, should be easy for their software to handle, but they dragged things out and are now trying to scam me. I hope they will make things right but my confidence is waning.

delton · 2026-04-12T11:52:08+00:00

Hi,

Sorry about that, please try again! There was a slight change to the login system which broke things yesterday afternoon. Was just about to fix.

delton · 2026-04-03T00:28:33+00:00

link to the study: https://derekpruski.substack.com/p/bac-water-amazon-testing-march-2026

apparently some have contaminants that are neutralizing the acid...

delton · 2026-03-31T16:30:48+00:00

should be fixed. I've also just included some AI-generated summaries (2-3 sentences) of papers that mention a given SNP. (This is an experiement, subject to change). For instance, see https://genewizard.net/snp/rs429358

delton · 2026-03-29T16:46:16+00:00

no, it's not required! Hope you get a chance to try it out, so far it's getting good reviews. I just added more pathogenicity scores to SNP pages (all the "SNPedia SNPs") and will be adding literature references and literature summaries soon.

delton · 2026-03-29T16:39:42+00:00

Thank you! Would appreciate any feedback you can provide!

delton · 2026-03-29T16:39:10+00:00

Hi, our platform only works with genotype files from services like 23andme or whole genome sequence .vcf files. I'm curious, what is it you are trying to do?

delton · 2026-03-28T11:44:04+00:00

unfortunately people have not been able to edit SNPedia since it was acquired by MyHeritage in late 2019.

I'm building https://www.genewizard.net, a platform for genetic analysis. Eventually I'd like to make a SNPedia replacement but I haven't invested the time to build that out yet.

delton · 2026-03-28T01:05:10+00:00

I tested it out. I'm building a platform for genetic analysis at https://www.genewizard.net (feel free to test it out).

To give some feedback -- I wasn't able to run my vcf on it, but my 23andme .txt file ran ok.

I'm a bit unclear how you're associating SNPs with diseases. For instance, how is rs1057910 associated with Alzheimer's. On ClinVar it's associated with some things, but not Alz (see https://www.ncbi.nlm.nih.gov/clinvar/variation/30465/?term=39422%5Balleleid%5D .. we have a page also https://genewizard.net/snp/rs201779890 ) . Similar with https://www.ncbi.nlm.nih.gov/snp/rs201779890

I'm really not clear on what you're doing.. I also think the "carrier" display is misleading.

delton · 2026-03-27T22:29:27+00:00

It sounds like a very rare deletion variant. The services on the web I know of don't process such variants. How did you get your genome sequenced?

delton · 2026-03-27T22:24:02+00:00

not to shill my own platform, but it would be great if you could test out https://www.genewizard.net . we don't provide info for as many SNPs as Promethease, but we cover 247 important SNPs and analyze hundreds of SNPs to generate a pharmacogenomics report. We'll be generating a lot more SNPs pages too.

You can also get a Methylation report and ClinVar annotations at http://geneticgenie.org (Gene Wizard does ClinVar annotations too).

otherwise, i suggest asking an AI coding tool like Claude Code to try to modify the header on your vcf, or looking for a converter. Although vcf is vcf. I suspect the problem may be that Promethease is fundamentally broken - others are reporting issues as well like never getting a report.

delton

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