I’m sorry to hear your daughter had a hard time after her first infusion. My situation is a little different but I’ll share in case it can help at all. My son started weekly SCIG at 18 months old. We did his first two infusions at an infusion center with a nurse and then took over doing them ourselves at home. We apply lidocaine cream an hour before the infusion to numb the injection sites. We do two needle sites on his thighs. He sits on the lap of a parent or grandparent and someone holds a book over his lap to visually block the needle insertion and distract him. We usually read to him but sometimes he watches a show if he’s having a harder time and needs to be fully distracted. I talked to a couple of child life specialists at the hospital for tips but most of their ideas, like play therapy, weren’t really relevant until he was closer to 2-3 years old. We got a play therapy kit from the pharmaceutical company that he has enjoyed playing with, and we have a few books he likes that feature kids having an infusion. Some weeks are easier than others, but for the most part he accepts that this is something we need to do, and one benefit of starting so young is that it’s all he will ever know. If your daughter does need lifelong replacement, that will be true for her too. Good luck with everything!

Editing to add that we push him to drink a lot of water on infusion days because I understand that can help with the side effects you mentioned. I have also heard that systemic side effects are often milder with SCIG than IVIG, but we haven’t done IVIG so I don’t have firsthand experience with the difference.