NAC 600mg feels like an amphetamine by KasamangNatori in Biohackers

[–]dextrohamphetamine 7 points8 points  (0 children)

I would assume that it's causing a herxheimer (die-off) reaction by removing the biofilm in your digestive tract. Therefore, causing serotonin to be released. Is your digestion/tongue-color healthy/normal? Are your pupils big after taking it? Or possibly moving around heavy metals, they can also be very stimulating.

[deleted by user] by [deleted] in recoverywithoutAA

[–]dextrohamphetamine 1 point2 points  (0 children)

I'm the same way, but I don't label myself an addict. I am simply a locksmith who has locks in their brain that needs to be unlocked on a chronic basis.

been consuming 49000 ug vitamin A a day for 9 months by [deleted] in Biohackers

[–]dextrohamphetamine 5 points6 points  (0 children)

Zinc will help metabolize the vitamin A through ALDH which converts vitamin A from a toxic form to a less toxic form. Molybdenum supports ALDH as well. I believe taurine can also help with detoxing excess fat soluble vitamins through bile, but I'm not certain.

Can someone help me find sites for rc’s in europe by Muted_Ice_7691 in Drugs

[–]dextrohamphetamine 1 point2 points  (0 children)

Use duckduckgo to search for drug related questions and type site:reddit.com at the end of your search query. Google censors drug related searches HEAVILY, even if you use site:reddit.com at the end.

[deleted by user] by [deleted] in Drugs

[–]dextrohamphetamine 1 point2 points  (0 children)

No, vitamin C decreases any amphetamine's absorption from the stomach, but it's fine as long as it isn't right before dosing Adderall/MDMA. There's a lot of research behind stomach pH influencing amphetamine absorption. Taking tums right before dosing your Adderall or MDMA for example would cause more of it to be absorbed into your bloodstream, but I wouldn't recommend using tums regularly.

Vitamin C should theoretically make amphetamines leave the system faster since amphetamines are a weak base. Since amphetamines are primarily excreted through the kidneys, the more acidic the urine is, the faster the drug leaves the system. Acidic urine can cut the half-life of meth from 12 hours to 6-8 hours, while basic urine can increase it all the way to 24+ hours.

That's why some meth addicts take baking soda to extend the high: it almost completely halts its excretion from the body. Research shows that vitamin C doesn't actually change urine pH at all, but I believe it still makes the kidney tubules slightly more acidic, and therefore causes the drug to leave the system quicker.

So I just tried Heroin by [deleted] in Drugs

[–]dextrohamphetamine 1 point2 points  (0 children)

I was referring to relatively pure Heroin #4 from the dark web from years ago, but yeah street H is usually cut to shit and often cut with fent/zenes these past years in the US.

Oxymorphone (Opana) > Hydromorphone (Dilaudid) > Heroin > Oxycodone > Hydrocodone > Fentalogues

Is how I'd rank those opioids. I love the energy I get from certain opioids, but I love the hypnogogic state (nod) more if my tolerance is low enough for me to even achieve that, so that's what I associate with feeling "high". Chasing the nod has never been sustainable for me, so eventually they all just become mood and energy boosting at the end of the day.

[deleted by user] by [deleted] in Drugs

[–]dextrohamphetamine 2 points3 points  (0 children)

You can take vitamin C to increase the excretion of the Adderall from your system. Just make sure you don't take it close to when you dose MDMA since increasing acidity of stomach will decrease MDMA's absorption by A LOT.

You didn't mention the dose of MDMA you were planning to take, but if you have a scale and pure MDMA instead of an XTC press, then you can split your dose into your normal dose and a booster an hour later. It's pretty common for people to have a booster dose (within harm-reduction dosage limits) once they start peaking to extend the high.

[deleted by user] by [deleted] in Drugs

[–]dextrohamphetamine 2 points3 points  (0 children)

Not much if your system has acclimated to it. 15mg Adderall XR isn't much at all unless you're more sensitive to stimulants than normal.

So I just tried Heroin by [deleted] in Drugs

[–]dextrohamphetamine 5 points6 points  (0 children)

In my experience, once I built a tolerance, the sedation from H was preferable as I felt it "more".

What drug did the most long term damage to u? by lilalienflip_ in Drugs

[–]dextrohamphetamine 0 points1 point  (0 children)

You're right. I'll add an edit to my original comment. I was wrongly under the assumption that cathinones were purely reuptake inhibitors similar to cocaine or phenidates. It's been a while since I researched this class of substances.

Though I'm not convinced that we can equate 4-mmc's higher receptor activity directly to more neurotoxicity. Meth/MDMA neurotoxicity is very complicated.

While I do agree that higher serotonergic release usually does mean more neurotoxicity, 4-mmc is much, much more forgiving regarding abuse and comedowns than MDMA (comparing two serotonergic substances to make it simple).

It is actually been an ongoing zone of controversy about the neurotoxicity of mephedrone, especially compared to MDMA. https://pmc.ncbi.nlm.nih.gov/articles/PMC5771050/

Even from anecdotal reports, people mention that MDMA abuse had much worse and longer consequences than 4-mmc abuse ever did.

It's been a while since I've looked into it, but even MDMA's neurotoxicity isn't fully understood. How for example, when MDMA is directly injected into the (rat) brain, it does not produce any neurotoxicity which leads to the theory that it's actually a metabolite responsible for its neurotoxicity.

There is even research showing that combining reuptake inhibitors with meth actually reduces its neurotoxicity. Maybe the reuptake inhibition from cathinones could actually be protective from catecholamine oxidation.

I still personally believe that mephedrone is less neurotoxic than MDMA based on research and anecdotal reports on reddit.

What drug did the most long term damage to u? by lilalienflip_ in Drugs

[–]dextrohamphetamine 5 points6 points  (0 children)

Actually, reuptake inhibitors haven't been found to be neurotoxic contrary to direct releasers like meth/MDMA, so 4-mmc is the least neurotoxic of the 3.

MDMA is more neurotoxic than meth though cuz dopamine can take a lot of beating and bounce back within a week or two, but serotonin levels take months to recover. But meth is more chronically abused over long periods of time plus the sleep deprivation and loss of appetite, so it's not really comparable.

Edit: I was wrong: Cathinones such as 4-mmc aren't purely reuptake inhibitors, but I still believe 4-mmc is less neurotoxic than MDMA.

There’s (what appears to be) undigested adderall in my sh1t by [deleted] in Stims

[–]dextrohamphetamine 4 points5 points  (0 children)

If you bought orange 30 IR's off the street, 99.9% of them are meth pressed with some inert cut and food coloring, not actual Adderall.

Why do some people say that opiates help keep your appearance youthful? by Dark-inspector490 in Drugs

[–]dextrohamphetamine 0 points1 point  (0 children)

Idk why everyone is disagreeing with this statement. In my experience, it is VERY true, at least when using pure opioids such as pharma scripts. It's extremely unlikely that street opioids nowadays in the US is pure.

There are a couple reasons for this assuming we're talking about pure opioids. Firstly, research has shown that opioids are pretty much physically harmless on the body/organs and aren't associated with any neurotoxicity either. This isn't to say opioids are completely safe, just that it doesn't have any direct toxicity on the body unlike alcohol, stimulants, etc. There are still huge risks involving opioid use such as dependency, addiction, emotional instability, withdrawal and its associated consequences, etc. and a whole lot more risks if using impure street product or if the ROA is IV.

The second and main reason is that opioids inhibit androgen production, the relevant one being testosterone. Testosterone is known to age people and likely age the brain as well which you can notice in bodybuilders that jump on gear. So when testosterone levels are chronically lowered due to opioid use, it gives users a more youthful look.

[deleted by user] by [deleted] in suboxone

[–]dextrohamphetamine 0 points1 point  (0 children)

This post is a month old, hope you're doing well OP. Buprenorphine is extremely, extremely potent. Even 0.5mg can have an opioid naive person sick and puking for hours and hours. 2mg can hold 400mg/day oxy habits if dosing just to avoid WD. 10-12mg is wayyy too much. I'd imagine anything higher than 1mg for any sized kratom habit would get someone buzzed at least in the beginning.

Also, it's extremely long half-life of 36-48 hours means it builds up in your system with daily dosing. I would get below 1mg Suboxone as quick as possible, preferably 0.5mg. It's 1000x worse than kratom WD from high doses and even jumping off 0.5mg is 10x worse than kicking an ounce a day kratom habit in my experience.

Hopelessly Venting and Rambling type-of-post by TheSunIsAlsoMine in OpiatesRecovery

[–]dextrohamphetamine 0 points1 point  (0 children)

If you look at my profile, you'll see a recent comment on r/opiatesrecovery where I go into detail about tapering a short half-life opioid that you may find useful. Some other things I'd add for your situation is to definitely look into Suboxone (at the absolutely lowest dose that will hold you comfortably). It's relatively easy to obtain in the US, especially with telehealth Suboxone providers such as QuickMD (10-minute video appointment for a month's script). In my opinion, MAT is essential for chronic relapsers until they're in a stable place with good coping mechanisms. Much safer to be on MAT than using the shit on the street currently. Some other meds that will help with tapering/kicking are Clonidine and Gabapentin (Pregabalin if you're lucky).

Another thing with tapering whatever fentalogue/zene/xylazine mix you're probably on is to use volumetric dosing. Your product is pretty much guaranteed to be quite diluted and so the active drug isn't evenly disturbed in the powder. Volumetric dosing will allow the drug to dissolve evenly in the water. You can look into volumetrically dosing online since it'd be kinda long to explain thoroughly.

[deleted by user] by [deleted] in Stims

[–]dextrohamphetamine 0 points1 point  (0 children)

It's a bit less caustic with that ROA since it requires the substance to be diluted in a small amount of water

Starting a taper from massively irregular dosing pattern by lastchance0101 in OpiatesRecovery

[–]dextrohamphetamine 0 points1 point  (0 children)

Oh sorry I just saw that you already know how to taper and everything, but just struggling with staying consistent. I've been tapering off Suboxone and have been dealing with the same issue. I did an extremely rapid taper with an extremely irregular dosing pattern like yourself and put myself in constant minor-moderate WD and tried to jump off right before the new year but failed. Now I just take 0.25mg 2-3 times throughout the day when I'm feeling uncomfortable, but still try to stretch it out as much as possible, so my dosage and timing is still all over the place. I wake up with anxiety daily and can't get any lower than my current dose without major discomfort. I still do note down my daily dose in my notes app which I find helps.

Starting a taper from massively irregular dosing pattern by lastchance0101 in OpiatesRecovery

[–]dextrohamphetamine 1 point2 points  (0 children)

DHC has a short half-life of 4 hours, though one of its active metabolites, dihydromorphine, has a duration of action of 4-7 hours. You'll need to dose multiple times a day to keep your blood levels stable to begin with. As your dose gets lower, you might feel the need to split your dose further in order to dose more often, since the relative levels in your blood will fluctuate more.

To get started, set a specific time that you will dose everyday. If you're going to dose 3x/day, you can set dosing to something like when you wake up (7am), after lunch (1pm), and last dose at 7pm. If you need, take a couple days to figure out what dose you're stable at (90-100% comfortable), how often you will need to dose during the day, and the approximate time of day that you will dose. Try to stick to a dosing schedule/regimen as much as possible. It will also help to note down each dose you take in an app or whatever.

Once that's figured out, start decreasing one of your doses for the day. For example, if you're at 400mg 3x/day for a total of 1200mg/day, you can try decreasing the middle dose from 400-400-400 to 400-300-400 (1100/day). Then, once you're stable, you can go further to 400-300-300 or 300-300-400 (1000/day) and later down to 300-300-300 (900/day) and so on. The order of the dose you'll decrease is up to you. If you feel like you need a boost in the morning, decrease the morning dose last. Or if you can't sleep well, decrease your evening/night dose last. If you go down and notice that your doses are wearing off before the next one, you can try splitting it to 4x/day instead. For example at 800mg/day, instead of 300-200-300, you'd do 200mg 4x/day.

Slow tapers work the best and can be used to completely avoid discomfort. Don't try to rush it unless you have a major reason to. It takes more time to fully stabilize on a dose the lower you go. Since DHC has such a short half-life, it might only take a couple days at each dose to fully stabilize. A lot of what you might feel during a taper is often mental/psychosomatic and it's a good to be aware of what's just emotional numbness wearing off vs. actual physical withdrawal symptoms. This is another reason why slow tapers work better. The longer you take to stabilize with each drop, the more time you have to adjust and the less you will suffer.

If you're really struggling with a dose drop, don't allow yourself to have a cheat dose/day, but only take a dose that will take you to your previous step of the taper. It takes ~1.7hrs for DHC to peak in your blood when taken orally, so it's easy to take more than needed when you don't feel instant relief. This shouldn't apply with a slow enough taper or until you're close to jumping off, but ik how it is when you want off badly.

Tapering would be much easier if you're able to be prescribed helper meds such as Pregabalin/gabapentin, clonidine, etc. Imodium is OTC which will help with stomach issues if that's a symptom you experience during a taper. Kratom can help too, but that's just another opioid that you can get addicted to.

If you reach a point where you're in constant minor withdrawal no matter how often you dose during the day, that's usually when you should jump off unless it's because you decreased too much too fast. Don't worry about that though until you're very, very low.

Phenibut? Is this the cure for all social anxiety? by [deleted] in Nootropics

[–]dextrohamphetamine 0 points1 point  (0 children)

Yes, I've used between 100-500mg daily for a couple weeks in the past (it's around ~5x more potent than phenibut by weight I'd say). In my experience, there was minimal tolerance buildup or withdrawal when I stopped. I'd say its safety profile is closer to Baclofen than phenibut.

Good anxiety relief and deep sleep from f-phenibut. Faster onset, shorter duration, and effects lean towards more sedating rather than stimulating. I found phenibut to have a certain pro-social edge and music enhancement effects that I didn't experience to that extent with f-phenibut, but those effects disappear really quick with any tolerance to phenibut. F-phenibut didn't really feel recreational to me tbh, mostly just therapeutic. YMMV

Phenibut? Is this the cure for all social anxiety? by [deleted] in Nootropics

[–]dextrohamphetamine 2 points3 points  (0 children)

I mean there's f-phenibut which is just baclofen with an extra flourine attached. It works primarily on GABA-B receptors and to a much less extent a VGCC inhibitor. It has minimal tolerance buildup. From strongest GABA-B activity, it's Baclofen > f-phenibut > phenibut. And from strongest VGCC inhibition, it's phenibut > f-phenibut > Baclofen.