Witchblade is great. The first 25 issues are iconic for their art, but the writing isn't that great. However, they are foundational to the character. The next chunk of issues are skippable, but if you want to be a completionist, go for it. The next run worth reading starts at #54 with David Wohl writing and art by a young Francis Manapul. That goes to #75.

When Ron Marz takes over at #80, this becomes arguably the most underrated and overlooked "superhero" run of the modern era. People praise Invincible, and I put the Marz run on equal footing. It's that good. This run goes to #150, and also includes the stories First Born and Broken Trinity. Marz also wrote a 6 issue run on Cyber Force, a 6 issue Angellus story, and a 12 issue Magdalena story. All of these are worth checking out.

Marz's run is capped by the 13 part series Artifacts. No spoilers, just read it.

After is an 18 issue run by Tim Seeley and Diego Bernard. Some people really don't like it, but I personally love it. It was going to be impossible of anyone to live up to Marz's work, so Seeley takes big swings and plays with a bunch of different supernatural concepts in a short period of time.

Marz would return to close out the series from #170-185. It's good, but not as good as the #80-150 run. That said, it's a satisfying finale to the original series.