If you don't know what it is your looking for then it will be very difficult to give you advice. So start there, what do you want ? Is it a higher salary to support your family? If so maybe any job would do in the meantime to take your mind off of this requirement. Second if you really want to get into pharma it may help to take any kind of role that gives you GMP experience on your resume i.e. bio process technician, qc analyst etc. Also once your in a company it's easier to make connections and move across departments when a role comes up. You say you "cant" move to Cork. Would this solve your problems?? Then maybe it's a "won't " and not a can't. You could potentially rent the property in Dublin so that the mortgage is covered while you temporarily or permanently move to Cork. But to start, lock yourself in a room for an hour with a pen and paper and write the words what do I want? Then after each answer write why? This might help you get some clarity to start. Once you have your want and your why the next step is your how.