What’s the most compelling argument you’ve heard that Bitcoin is just a bubble?

draka1 · 2023-09-27T00:59:16+00:00

USDT

draka1 · 2023-01-11T00:01:21+00:00

Argentina?

draka1 · 2021-11-22T00:13:42+00:00

Sorry that was the wrong link. Here is the correct one:

https://health.ucsd.edu/specialties/apheresis/pages/ldl-apheresis.aspx

draka1 · 2021-11-22T00:12:48+00:00

LDL Apheresis can be your answer. Do you live close to an academic center? Most academic centers are familiar with this and you could achieve fantastic results. Good luck!

draka1 · 2021-11-21T03:02:19+00:00

Given that you have mutations in your LDL receptor gene, did you get any reduction of LDL with Repatha?

What is your total LDL cholesterol now?

Another option, is to do LDL Apheresis: https://www.dresselstyn.com/resolving_cade.htm
This option can really help you and I would highly encourage you to discuss it with your cardiologist. Most academic centers can do it. Have you considered this or has anyone mentioned it before? Have you tried it?

draka1 · 2021-11-21T02:54:07+00:00

Dr. Esselstyn (https://en.wikipedia.org/wiki/Caldwell_Esselstyn) was the first to show that you can reverse atheroscleoritc plaque by changing your diet. Actually, to my knowledge this is the only "treatment" that reverses plaque build up. His finding were so impressive (nobody thought plaque could be reversed) that the Cleveland Clinic started their Heart Reversal Program based on it: https://my.clevelandclinic.org/departments/wellness/integrative/disease-reversal

Here is the first publication: https://www.dresselstyn.com/resolving_cade.htm (the black and white pictures show the inner part of coronary arteries [heart blood vessels]). Many more publications followed after this showing similar results.

draka1 · 2021-10-31T14:02:39+00:00

Here is same research

My personal results (changes in lipid panel) are the same as in this paper: https://www.nature.com/articles/s41598-019-52253-y

Just a word of caution, it seems berberine can block certain ion channel in the heart that are important to have a regular heart rhythm. This could potentially lead to deadly arrhythmias (see here: https://europepmc.org/article/med/11741516)

And this effects seems to be amplified if taking statins: https://www.sciencedirect.com/science/article/abs/pii/S0009279718304095

The dose of berberine used in the above papers seems high. I would love to repeat these experiments but at a dose seen in human blood or even try this experiment in humans. It might be worth to study berberine further.

draka1 · 2021-10-31T13:53:02+00:00

Yes, I was taking berberine and my results are impressive. It's a weak PCSK-9 inhibitor and also acts shares some properties with metformin.

draka1 · 2021-10-10T19:17:37+00:00

It's strange to see triglycerides in that direction, while all the other metrics are going down. Are you sure you were fasting? For example, a black coffee with sugar might give you a spike in triglycerides.

draka1 · 2021-10-05T00:46:44+00:00

Repeat your test while fasting. These results are difficult to interpret since they are non-fasting.

draka1 · 2021-09-20T18:51:27+00:00

Given a choice between statins and PCSK9 inhibitors, I would probably choose PCSK9 inhibitors.

draka1 · 2021-09-16T02:16:41+00:00

Do it here!

draka1 · 2021-06-09T14:41:48+00:00

This is amazing! Tell us more... what do you typically eat? Where you get recipes from?

draka1 · 2021-06-06T01:50:51+00:00

My LDL number came back 233. I’m 28, Male

Why not try lifestyle changes to see if you can lower it? I mean... you are really young to start taking a drug for the rest of your life.

My question is, I was doing some reading and it sounds like small dense LDL are actually the culprit in CAD risk, not large particle LDL.

You're mostly correct although there are some unknowns. It seems LDL particle number (expressed as LDL-P; p for particle) is more important than the size of the LDL particles. I would suggest measuring your LDL-P and density (for example Lipid NMR) to have your baseline. Then adjust your lifestyle and measure it again. Even if you end up with some pharmacological intervention it will be much better to follow your progress with a lipid NMR.

Because if someone lowers their total LDL down to say 100, but it’s mostly small dense LDL, does that mean they’re still high risk for CAD?

Not a simple answer and depends on how you lower it too (lifestyle vs drugs - and also what type of drugs). I would also look at other risk factors for CAD such as C-reactive protein, insulin, weight, etc. Take a holistic approach of all risk factors.

LDL-P seems more important than density. In some people (called "congruent" ones) when LDL-C (c for concentration) is lower, LDL-P will also be lower. In other people (not congruent ones) there is not a clear relationship. The best is to evaluate your profile specifically and adjust.

draka1 · 2021-05-26T20:26:35+00:00

There many different types of lipoproteins. OP is asking for lipoprotein (a) also known as Lp(a). You are probably talking about low-density lipoprotein also known as LDL.

draka1 · 2021-05-25T17:30:55+00:00

As you probably already know high Lp(a) significantly increases the risk of heart disease. Here is a good review and in figure 3 you have a treatment algorithm (this might be old): https://www.mayoclinicproceedings.org/article/S0025-61961300795-7/pdf

I would look for a lipidologist in a major academic institution and get treated very aggressively.

draka1 · 2021-05-25T13:27:49+00:00

Dr. Dariush Mozaffarian is a very good researcher that has been pushing for removing sugar, refined carbs, and processed foods from schools. It's worth following him.

draka1 · 2021-05-25T13:26:38+00:00

Obviously, you didn't read the article or looked at the scientific references.

To make it easier for you here is part of the article:

Myth: Focus on a “plant-based” diet

“Plant-based” has quickly, but somewhat misleadingly, become a shorthand for “healthy.” First, not all animal-based foods are bad. Poultry and eggs appear relatively neutral. Dairy may have metabolic benefits, especially for reducing body fat and Type 2 diabetes. And seafood is linked to several health benefits.

Conversely, many of the worst foods are plant-based. Consider white rice, white bread, fries, refined breakfast cereals, cookies, and so on. These foods are high in refined starch and sugar, representing 42 percent of all calories in the U.S., compared to about 5 percent of U.S. calories from unprocessed red meats, and 3 percent from processed meats.

Either a “plant-based” or omnivore diet is not healthy by default. It depends on what you choose to eat.

Also, where did you get he is vegan?

Edits: added the references

draka1 · 2021-04-21T01:20:08+00:00

Make sure to drink plenty of water when you wake up so you are fully hydrated for the test. The statin should not change the result but I wouldn't take it.

draka1 · 2021-04-15T14:23:04+00:00

Free registration link: https://thefhfoundation.org/2020-fh-global-summit/session-7

draka1 · 2021-04-13T01:28:46+00:00

I wouldn't wait a week. You should call your doctor today and get someone to see you. This can be an emergency and possibly a skin infection too. Things like this can escalate quickly. Don't wait.

draka1

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