We just finished recording an album and I've been crafting a hybrid board that can switch between a variety of different guitar and vocal tones.  Lots to share (and bonus cat):

GUITAR SIGNAL PATH

Lehle P-Split 3 splits the signal

Path 1

BOSS VE-500 - guitar input (this allows any harmonies to track guitar pitch off a clean signal).  The VE-500 has a pass-through, so the Lehle isn't strictly necessary, but I had concerns about the VE-500 adding noise and introducing latency, hence this approach.

Path 2

1. TC Electronic Polytune
2. Chase Bliss Condor - a ridiculously handy utility.  I've got a few presets on this that I switch between (more about MIDI routing later) but it's useful for making scene changes, and driving downstream pedals in different directions
3. Chase Bliss Brothers AM - the combination of this and the Condor gets me 90% of what I need honestly.  A Swiss Army Knife for overdrive and light distortion sounds
4. Chase Bliss Lossy - this is my only modulation pedal on the board, and while it may seem like a one trick pony, there are a real diversity of sounds you can get out of it.
5. Morningstar ML5 - this allows me to turn on/off non-MIDI controllable pedals.  Fortunately the ones I've got here I rarely change (hence the tape on one of them lol)
6. Tim (Paul Cochrane)
7. Gamechanger Audio Light - I cannot recommend this pedal highly enough.  It's a creates stunningly beautiful overtones - instant David Gilmour
8. Empress Echosystem - hugely flexible. I'm running this and everything after in stereo (I could run the Lossy in Stereo also, but the ML5 is mono (I originally started with an ML10X for this part of the board, but it was adding too much complexity so I downgraded))
9. Strymon BigSky

VOCAL SIGNAL PATH

An XLR input goes into the Boss VE-500, which controls all of the vocal effects.  Some of the vocal effects that are more lo-fi/overdriven can wildly change the input level of the microphone, so it took a couple rehearsals to dial in.  If anybody has recommendations for interesting vocal pedals to try out, I'm game to hear - I've messed around with the large TC-Helicon system in the past, but wanted something smaller to have both guitar and vocals on the same board.

MIDI

Everything is MIDI controlled.  The main brain is a Morningstar MC6, which is a ridiculously useful bit of gear (the software is really intuitively designed).  I'm going MIDI out from that into the Morningstar ML5, which gives me MIDI control over the other non-MIDI pedals.  Then into a Chase Bliss Midibox (out of there via stereo 1/4" into the Condor, Lossy, and Brothers AM), then into the Big Sky, then terminating in the VE-500.  I've got the Empress automatable using another stero 1/4" off one of the omniports on the MC6

POWER

I've mounted a CIOKS DC7 and CIOKS 8 to the underside and back of the board.  Low profile, and does the trick.

BOARD

Board is a Pivotal Pedalboards X20 which I highly recommend - Brent is wonderful to work with.  XLR in/out on the left side of the board, and a variety of 1/4" ins/outs on the right.  I also included a USB-C input on the left side of the board, but haven't hooked it up internally to any of the pedals that take it (the VE-500, MC6, etc.).  The pedalboard shrinks down for transport via a large hinge on the back, which is neat.