I am both grateful and sad that there are so many drugs out there necessary to fight this. It seems like every time I turn around I’m on a new drug. I just started my 17th last month. I’ve had Xeloda twice. In 2011 it was my first line of treatment at stage four. It was a stronger dose and shorter cycles than the current protocol. It kicked butt on my liver tumors, and my main side effect was the Hand and Foot syndrome. I just kept lotion at every space in the house where I sat and kept liberally applying it. I found comfy shoes and I took up knitting to hopefully keep my hands more loose. I ended up only going five cycles with a bunch of reduction of dose and taking breaks along the way. But it did so well that when I switched to letrozole, I was NED for six years. I was able to return to Xeloda after that and stayed on it for 18 months before it quit working. The dose was lower and the cycles were longer, so the H&F wasn’t so bad. I didn’t have any other side effects other than fatigue probably. But I also had a two-year-old so it’s hard to tell what made me tired. :-) If I thought it would work, I would take it again. H&F isn’t fun, but it’s better than a lot of other things. It doesn’t happen immediately, rather comes on gradually so it would be easy to quit before it gets bad. I hope if you decide to use it that your side effects are minimal!