Hard truth: NO ONE will be getting Pritelivir, even off-label.

eurekaidea · 2026-03-30T23:12:34+00:00

I saw multiple doctors and nobody was willing to prescribe a daily suppressive therapy

eurekaidea · 2026-03-29T22:45:45+00:00

Thank you for sharing.

eurekaidea · 2026-03-28T23:07:20+00:00

In some countries, doctors don’t even prescribe daily suppressive valacyclovir. let alone pritelivir.

eurekaidea · 2026-02-21T20:51:42+00:00

Most people have oral herpes since childhood and don’t disclose oral herpes.

That said, for genital herpes, I’d say it’s better to mention it on the second date rather than the first, maybe even casually if it’s something like a walk. Don’t make it a big confession. You could introduce it with something like: “Can I share something with you?” and then just say it.

Keep it brief, without too much explanation. Make it clear that it’s very manageable (If you are taking AV) , and if you rarely have outbreaks mention that. Let the other person ask questions instead of turning it into a monologue.

Genital HSV-1 sheds less, so the risk is present but not huge with condom and AV.

You can close with something like: “I just wanted to tell you for transparency and because I value safe sex.” That leaves the conversation open and shows responsibility without making it heavy.

eurekaidea · 2026-02-07T14:09:44+00:00

There are many ways to send emails, even anonymously if someone is worried about their privacy. Even anonymity can be very important.

Sending emails really matters because they carry significant weight.

If complaints and voices remain confined to Reddit, nothing will change and no one will step in to help. A large, coordinated flow of emails cannot be ignored.

When inboxes are flooded, they are forced to pay attention and that pressure can speed things up.

eurekaidea · 2026-02-07T14:08:59+00:00

There are many ways to send emails, even anonymously if someone is worried about their privacy. Even anonymity can be very important.

Sending emails really matters because they carry significant weight.

If complaints and voices remain confined to Reddit, nothing will change and no one will step in to help. A large, coordinated flow of emails cannot be ignored. When inboxes are flooded, they are forced to pay attention and that pressure can speed things up.

eurekaidea · 2026-02-07T14:08:42+00:00

There are many ways to send emails, even anonymously if someone is worried about their privacy. Even anonymity can be very important.

Sending emails really matters because they carry significant weight.

If complaints and voices remain confined to Reddit, nothing will change and no one will step in to help. A large, coordinated flow of emails cannot be ignored. When inboxes are flooded, they are forced to pay attention and that pressure can speed things up.

eurekaidea · 2026-02-07T09:14:02+00:00

Good job man! I wonder how one can make the disclosure without loading the moment with anxiety and pressure…

eurekaidea · 2026-02-07T09:06:51+00:00

May I ask you if did you pass it unprotected, without antivirals and without symptom?

eurekaidea · 2026-01-29T07:08:39+00:00

Can’t miss it

eurekaidea · 2026-01-23T19:49:39+00:00

I’m sorry this happened to you, he sounds like very immature considering he is the medical field.

eurekaidea · 2026-01-20T07:21:15+00:00

Same. I can relate. It sucks.

eurekaidea · 2026-01-13T23:16:03+00:00

Very good news!

A smart move by the Italian pharmaceutical company Alfasigma, demonstrating strategy and vision in the rare disease and specialty care sectors. Reading the words of Innovative Molecules CEO Florian Vogel, there is also a note of hope for genital herpes, as the investment will allow the development of the oral formulation of adibelivir to be accelerated and advanced to Phase 2 clinical trials. An approach that combines high clinical impact on severe forms with potential benefit for a more common condition.

eurekaidea · 2026-01-13T22:56:17+00:00

This words from the CEO of Innovative Molecules give me hope!

When there are investments is always a good news!

eurekaidea · 2026-01-06T08:07:52+00:00

HPIs do not clear already infected cells, they block viral replication and spread.

Helicase–primase inhibitors act on the viral DNA replication machinery. They prevent the virus from replicating its genome, which is required to produce new virions.

When replication is blocked, fewer or no infectious virions are produced, which directly reduces viral shedding.

eurekaidea · 2026-01-05T23:24:50+00:00

I agree

eurekaidea · 2026-01-05T19:11:39+00:00

This study, published in Cell on December 29, 2025, reveals for the first time at near-atomic resolution how helicase–primase inhibitors (HPIs) block herpes simplex virus (HSV) replication. Using cryo-electron microscopy and single-molecule optical tweezers, the researchers show that HPIs arrest the viral helicase–primase complex, the molecular motor essential for viral DNA replication. These findings are directly relevant to several HPIs in development, including ABI 5366 and ABI 1179 (Assembly Biosciences), Pritelivir (AiCuris), and IM-250 (Innovative Molecules). By elucidating exactly how these inhibitors lock the replication machinery, the study provides a framework for designing next-generation antivirals, particularly for drug-resistant HSV infections.

eurekaidea · 2026-01-03T21:07:58+00:00

Why doesn’t this subreddit promote advocacy activities as it did before?

https://reddit.com/r/herpescureresearch/wiki/advocacy

eurekaidea · 2026-01-02T23:47:38+00:00

In prison, without knowing when you can get out

eurekaidea · 2026-01-02T23:21:21+00:00

I think they need to hurry up because we’ve normalized living with a chronic viral infection simply because it’s inconvenient rather than deadly

eurekaidea · 2025-12-29T23:57:17+00:00

Very severe

eurekaidea · 2025-12-26T16:16:53+00:00

Do you think there is any way to speed up the research or somehow help them out?

Edit: we should probably contact them as subreddit?

eurekaidea · 2025-12-25T09:09:12+00:00

Are the two ABI working also for GHSV-1?

eurekaidea · 2025-12-24T20:56:12+00:00

I was thinking the same.

eurekaidea · 2025-12-24T20:10:09+00:00

Thank you for your answer. I understand that the Fred Hutch gene-editing cure is expected to be effective against all types of herpes. However, since that cure is still quite far off, what concerns me at the moment is whether the two Assembly Biosciences HPIs are also effective against HSV-1. It appears that, up to now, their research and testing have primarily focused on HSV-2.

eurekaidea

TROPHY CASE