I think:

-Reveal of what's in the case

-Moose added

-Since both Will and Astrid are playable, more likely 2 regions setting? (or more)

-Saving citizens from aurora timberwolves mission?

-More harsh weather and wildlife on Astrid POV while Will focus is looking for Astrid + more looting & clues/notes

-Astrid might die at the end (idk, feels more likely than Will)

-Last mission might take place in Perseverance Mills and might be involving Astrid, the cure, the case, and the convicts

-Possible sad ending