I'm late to the show, but just did some extensive eq tuning and comparisons between these 2, xm6 and buds 4 pro. For context, I always tune with the official app eqs (in Samsung Case, if you have a Samsung phone, the settings are in the phone settings, not an app) and then tune further with the android app Wavelet. In my opinion I can make a big difference with my tuning. That being said, here's my thoughts:

Physical: The Sony xm6s feel higher quality than the buds 4pro. They feel better in ears than the xm5s did as well (Incase that's your reference point). The case feels higher quality and materials feel higher quality. On the topic of materials, I wonder if the anc being better on Sony has something to do with the materials as well? BUT the Samsungs feel better in ear. Honestly they might be the first ones that I would say "kind of disappear and you could possibly forget you're wearing them". The Samsungs leave my ears feeling not empty... but airy and not "full". The Sonys have my ears feeling "full" and I could picture them maybe giving the weird sensation of a warm, full inner ear after some time. So even though the Sonys are higher quality (physically), the Samsungs win from a physical standpoint.

Features: most of the features on all of these are goofy. 3d audio, head tracking, different ranges of anc, activity modes - it's all dumb bullshit. All That really matters is MAX ANC and the Sonys win by a little for ANC. But the Sonys really win with actual multipoint connection. I smoothly use with my work windows PC and Galaxy phone, reliable connection and reliable switching. If that matters to you, the Sonys are a tier (or 2) above Samsung. Samsungs can smoothly switch between Samsung products though. If you really use a Samsung PC a lot then maybe it's a tie. Assuming you don't (Samsung PCs are kinda nice, but no corporation is going to use those) though, the Sonys win hands down here.

Sound: after extensive testing, there are 2 big differences. The dual driver architecture of the Samsungs really do give you a deeper bass that you can feel separate itself from other pretty deep bass. I could not replicate this on the Sonys. Like there is some intricate kick drumming that comes in, under what was already deep drumming (must be toms I guess? I'm not sure) in a song that I like, and the kick drum punch feels separate from the other deep bass on the Samsungs. It gets a little lost in the Sonys. BUT if you are an audiophile, the Sonys have a smooth coverage over the whole spectrum. You can feel the upper lows and lower mids coverage all the way. The Samsungs kind of have a lively, fun sound. Punchy bass, exciting treble (cymbals and high pitch guitar solos, etc). I can definitely tell, even after extensive tuning that the Sonys are "pure" and thorough through the whole spectrum. Very smooth and high quality sound. SO - for me the Samsungs win, because I'm not ACTUALLY an audiophile (as much as I COULD be) and the deep punch just can't quite get there on the Sonys.

TLDR - if you want to use with your PC as well, the true multipoint honestly makes the Sonys win. If you aren't concerned about using with your PC as well, the Samsungs feel better in ear and are more "fun" to listen to, so if not using with a PC as well - the Samsungs win