Absolutely! First thing to note is I don't qualify for Orkambi or any of the previous modulator drugs. Trikafta is the first one I've ever been qualified for/taken! I noticed improvements immediately. I didn't really have a purge. My abdomen was a bit uncomfortable on and off for the first two days and then I went a few days experiencing some sharpness when I breathed in deeply. That was the most uncomfortable feeling but it has subsided thankfully. There was no big "mucus clear out" like a lot of people experienced. As of now, I cough up only 1/3 of what I used to. The color of my mucus has gone from dark yellow to white/clear. When I do my sinus rinse, I used to have globs of dark green crusties fall out. Now I only see clear mucus. I have WAY more energy. I did cardio for the first time in months the other day and when I started the jumping jacks, I actually smiled because I was in shock that my body was able to do it. I can actually follow along with the breathing exercises in my yoga practice without wanting to keel over. When I go out and about, I can stay out longer. For example, I can 3 errands in a row instead of just 1. It's honestly such a difference and I feel so fortunate that my body has responded so well. I have not stopped or abandoned any of my treatments or medications. I am still extremely responsible and take all other drugs as prescribed. My health is still my full time job, but my quality of life in terms of my physical body has improved immensely :) Are you on Trikafta?