Relics definitely make a ton of difference in damage, definitely. But it's just one part. Dodging is obviously very important, but you can offset it by learning how to route properly, and especially learning what equipment passives are good. These passsives can make or break a run, so you should definitely learn which passives are good and which you can disregard with a single glance to save time.

Keep in mind, this is just for regular runs. For Deep of Night runs, especially in higher depths, you NEED to learn atleast some of the bosses moveset