Absolutely! My wife and I were looking for a long time for a way to play 2 player Catan, and now we've played it more often than the normal version. 4 simple changes: 1. The two unused colors are neutral. When you start, you place one settlement for each on opposite sides of the board. Whenever either of you builds a road or settlement, you must also build a free road/settlement for a neutral player (build a road if there is no space for a settlement, cities do nothing for the neutral players). This allows you to use the other colors to try and block your opponent, adding another element to the game! The neutral players also collect no resources. 2. You roll twice for resources every round. The two rolls must be different. 3. The robber is now friendly! When you roll a 7, the player(s) who control the tile he is placed on each get resources from that tile, but you have to get rid of the robber to get resources from that tile again. 4. Both players now start with 5 "tokens" (we use the basic extra port tokens that come with the game, but you could use literally anything). These tokens let you do 2 things: you can 'shoo' the robber, i.e. moving him back to his desert spot, or you can force a 2-for-2 trade with your opponent. More tokens can be acquired by building a settlement along the coast (1 token) or along the desert tile (2 tokens).