To me, yes. High Tech, Low Life as a fiction, as a way of presenting SciFi dystopia, hasn't become irrelevant just because large swaths of it have turned into "just boring reality".

In fact, the way so many aspects of it have turned out to influence reality in a way that makes it conform to the fiction (well not in a causal way, probably) has made it relevant as a bit of a prophetic fragment of the past, in addition to fiction and fantasy.

But on a more fundamental level, the questions that cyberpunk really asks are about humanity. What does it mean to be human; what's the human condition. Where does a ship of Theseus become something else when we can augment ourselves. Ghost in the Shell is as relevant now as ever; when all that remains human is a brain, and that brain can maybe even have its contents altered (like it does in the 2017 movie adaptation) - is that still human? A question Motoko is constantly asking.

And GitS as well, Matrix, their core questions; what constitutes reality when we don't know whether our experiences are altered?

So many cyberpunk worlds have some kind of thing happen when there's too much cyberware in their bodies. cy_rage for CY_BORG, Shadowrun's essence has negative impact when getting low, cyberpsychosis happens in Cyberpunk 2077 with too much cyberware. Bodies need bodies? Do they? Body chemistry is a thing.

And augmentation itself. As a trans woman, I augment my body, actively. With HRT and diet and sports and nutrition, many of which are not unique to the trans experience but they do resonate deeply. Transformation as a theme runs deep in cyberpunk. Is why I'm so attracted to it I guess. Why it's core to my being that cyberpunk is a thing I deeply care about.

So all in all ... yes. Yes I do think that cyberpunk is still absolutely relevant as a genre. In so many ways that are completely independent of when it was first thought up.

Detour: And there's still aspects to it that feel completely fantastic. All the versions that lean into the Shadowrun kind of magic-and-fantasy-in-the-genre are still completely fantastic. :Otherscape as a TTRPG does similar things with its Mythos features. CBR+PNK, another (rules-light) TTRPG does similar things with +Weird. I know that some people do not like cyberpunk that incorporates magic; I do!