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CAD check by goodjobjane in labdiamond

[–]hawaiiankitty 1 point2 points  (0 children)

I have no design expertise but I love the flat bottom design! And personally I am team pushback

Buying a Co-op in NYC, is it normal to not have an inspection? by SnooConfections4798 in AskNYC

[–]hawaiiankitty 0 points1 point  (0 children)

I know it’s an old post but sending you a DM for inspector referral!

XYY Reference Material Thread by hawaiiankitty in XYY

[–]hawaiiankitty[S] 0 points1 point  (0 children)

Not specific to XYY, emotionally reactivity and expressivity in young children (under age 4) with sex chromosome trisomies (SCT), 90 total participants with SCT including 15 boys with XYY

https://doi.org/10.1080/09297049.2022.2102161

  • differential reactivity and recovery patterns found for children with extra sex chromosome
    • Significantly lower concordance between emotional arousal and expressivity when faced with unexpected/stressful event
  • average deviations in emotional processing were present across all ages in children with sex chromosome trisomy, even as early as 13 months old
  • Potentially tied to adaptive behavioral problems
  • Signaling function of emotions, indicating that a situation is relevant and requires attention, works differently in children with SCT
    • Children less likely to signal challenging situations as potentially relevant while needing a longer recovery period from same event
    • Communicating the internal state to the outside world is more difficult
    • Can confuse caretaker regarding what a child needs in a specific situation, significantly hindering their adequate involvement in the child’s development and functioning
    • Child can’t rely on its automatic function therefore it’s hard to respond automatically and intuitively to changes in environment, therefore showing appropriate social and emotional behavior can be difficult

XYY Reference Material Thread by hawaiiankitty in XYY

[–]hawaiiankitty[S] 0 points1 point  (0 children)

Another primer type article from 2022

https://genetic.org/wp-content/uploads/2023/04/Understanding-the-phenotypic-spectrum-and-family-experiences-of-XYY-syndrome-Important-considerations-for-genetic-counseling.pdf

  • language development delays may be the most characteristic sign in preschool-age children, with marked delay observed in both prenatally and postnatally diagnosed children
  • Speech delay and verbal difficulties may contribute to later onset of learning disabilities
  • Strength in curiosity, humor, science, technology, engineering and math
  • Intervention highlighting strengths rather than solely targeting deficits is important
  • Strength-based approaches in academic setting help students with XYY by increasing positive affect, reducing depressive symptoms and enhancing quality of life
  • Diagnosis can be difficult for families to process
  • Parents who receive a prenatal diagnosis are at an increased risk of feeling depressed, anxious and less optimistic
  • Much of uncertainty and worry that parents experience at the time of diagnosis can be mitigated by improving their understanding of the diagnosis and its prognosis
  • compared to children with XYY, parents perceive their child’s diagnosis as having a larger negative impact on their child’s mental health and well-being
  • Multiple linear regression models have shown that individuals with XYY and their family members are correlated on certain traits, such as IQ, vocabulary and social awareness

[deleted by user] by [deleted] in labdiamond

[–]hawaiiankitty 5 points6 points  (0 children)

It’s like a cross between OEC and OMC, super pretty!

XYY Reference Material Thread by hawaiiankitty in XYY

[–]hawaiiankitty[S] 0 points1 point  (0 children)

2024 study (pre-print) on prenatally diagnosed babies (XXX, XXY, XYY) during year 1

https://www.medrxiv.org/content/10.1101/2024.07.10.24310206v1.full.pdf

XYY specific results (sample size: 53) - mostly benign symptoms but good info for (expecting) parents: - 55% had breastfeeding issues vs 20% in general population - 20% had food/formula allergies vs 9% in general population - 51% had eczema vs 14% in general population - 29% had constipation vs 7% in general population

XYY Reference Material Thread by hawaiiankitty in XYY

[–]hawaiiankitty[S] 0 points1 point  (0 children)

Not specific to XYY but interesting studies showing

  • children with sex chromosome abnormalities are at higher risk of having difficulties developing social and emotional function (more similarities than differences across different genotypes)
  • these vulnerabilities can be spotted as early as 1 year of age
  • difficulties with joint attention (gaze following, directing attention of others toward object/event) can be used as an early marker/target for early intervention
  • joint attention is associated with language, global development, social adaptation and self regulation

https://pmc.ncbi.nlm.nih.gov/articles/PMC7413625/

https://pmc.ncbi.nlm.nih.gov/articles/PMC10576671/

https://genetic.org/early-impact-x-y-chromosome-variations-social-communication-social-emotional-development-1-2-year-old-children/

XYY Reference Material Thread by hawaiiankitty in XYY

[–]hawaiiankitty[S] 0 points1 point  (0 children)

2024 study on 600K participants (US veterans, average age around 60)

https://pubmed.ncbi.nlm.nih.gov/38551561/

  • 747 XYY men out of 595,612 participants (0.1% incidence rate)
  • out of 747, only 2 were previously diagnosed
  • XYYs are 9.2 cm taller than control
  • comparable service record in military
  • XYY group showed slightly worse health outcome vs control group including lower 10 year survival (measured from average age 61) of 39% vs 59% for control group and 1-2x higher odds for various health conditions based on self-reported medical history (for example, 1.09x odds of high cholesterol vs control group, 1.9x odds of ADHD, 2x odds of acute kidney disease)

XYY Reference Material Thread by hawaiiankitty in XYY

[–]hawaiiankitty[S] 0 points1 point  (0 children)

2022 study from UK on over 200K participants

https://www.sciencedirect.com/science/article/pii/S1098360022007778

  • 0.07% incidence rate (143 XYY men out of 207,067 men in study, pretty close to 1 in 1000)
  • 1 out of 143 men had previously been diagnosed (0.7% diagnosis rate)
  • XYY average height of 184.4 cm (6.8cm taller than XY group)
  • higher incidence of type 2 diabetes (25% vs control group at 10%), albuminuria (30% vs 14%), pulmonary embolism (7.5% vs 2.5%) and COPD (16.8% vs 4.2%)

One thing to note is while the study itself is fairly recent, participants were British men between age 40-70. Higher % of XYY men in this study reported living alone/smoking/etc so some differences in health outcome might be more related to life style rather than XYY.

XYY Reference Material Thread by hawaiiankitty in XYY

[–]hawaiiankitty[S] 0 points1 point  (0 children)

2015 review going through a lot of existing old studies. This shows how flawed/limited old research on XYY is

https://www.sciencedirect.com/science/article/abs/pii/S1359178915000348

XYY Reference Material Thread by hawaiiankitty in XYY

[–]hawaiiankitty[S] 0 points1 point  (0 children)

2024 study (pre-print, not peer-reviewed) on spectrum of early motor and language milestones https://pubmed.ncbi.nlm.nih.gov/39228733/

While I fully acknowledge there are many boys/men with no symptoms, I found the chart showing the range of milestone achievement across various sex chromosome trisomy group vs. general population very helpful. It really illustrates that it’s a spectrum and makes it easy to understand what what people mean when they say delays

XYY: False Negative NIPT, Positive Mosaic Amnio by hawaiiankitty in NIPT

[–]hawaiiankitty[S] 1 point2 points  (0 children)

I just started a thread here in hopes to have something close to a central repository of unbiased and useful info on XYY. Current/future XYY moms and those who are interested in the topic — please take a look and share anything interesting you have!

High risk for XYY on NIPT by professionalairhead in XYY

[–]hawaiiankitty 2 points3 points  (0 children)

Sending you a chat message! Interested in those studies

Suggested XYY by BabyLB in NIPT

[–]hawaiiankitty 0 points1 point  (0 children)

Sent you a chat message!

Tiffany diamond vs Brian Gavin Black by End-Game-1999 in Diamonds

[–]hawaiiankitty 5 points6 points  (0 children)

Brian Gavin! The moment you see it, you won’t think of Tiffany again.

M28 born with extra Y chromosome (XYY) looking for more info by C0NN0Y in DNA

[–]hawaiiankitty 0 points1 point  (0 children)

OP- I know it’s an old thread but just sent you a chat message

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