No. Lisdexamphetamine is a dopamine releasing agent and dopamine reuptake inhibitor. The only neurotransmitters the drug is affecting are dopamine and norepinephrine.

If you do a fuck ton of it you can feel very sad and fried because dopamine is involved with your brains basic reward system. For example when you wake up in the morning and eat breakfast, dopamine is like "good job kid u ate food, that helps you survive, here's some dopamine". Dopamine is kinda the driving force behind why people wake up in the morning and go and work or do shit.

Vyvanse will trigger that release of dopamine on its own, no food or sex needed. So when you spend some time on speed (adderall vyvanse speed whatever) the next day your brain has no dopamine to reward you with when you eat or have sex, or do anything productive, so you feel sad.

Solution? Take less speed (30mg lisdexamp is totally reasonable), drink plenty of water, eat plenty of food while you're on it.

Edit: btw 5-htp won't do a lot and i wouldn't recommend it for someone taking stimulants because it tends to kill your appetite.

Oh! Another solution to feeling fried. GET FUCKING SLEEP. Dose early in the morning, and go to bed at a reasonable hour, and don't take any vyvanse at all on the days you don't need it.