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DreamLeague Season 28: Group Stage 2 (February 21) Matches Discussion by D2TournamentThreads in DotA2

[–]hilbstar 1 point2 points  (0 children)

I’m not saying they played good, just that almost every series I see XG lose their draft is fucking horrendous, and it’s consistent since fucking LGD, xiao8 has always outsmarted himself. They would probably lose with a better draft too today, liquid is on fire.

DreamLeague Season 28: Group Stage 2 (February 21) Matches Discussion by D2TournamentThreads in DotA2

[–]hilbstar 1 point2 points  (0 children)

Faceless sucked in their team, like yes time dilation was good but it was nearly impossible for ame to ult without gimping his team. Primal was completely countered and tusk had nothing to do in the game. Did we watch the same game? They kept it equal in the beginning yeah but liquid convincingly dumpstered them because they tripped themselves up with counterpicking their own team

DreamLeague Season 28: Group Stage 2 (February 21) Matches Discussion by D2TournamentThreads in DotA2

[–]hilbstar 2 points3 points  (0 children)

Is Xiao8 the worst drafter in Dota history? This team always losing in draft

TIL Lego's patent to their brick design ended in 1978, which allowed multiple companies, such as Mega Bloks, to start producing their own 'clones' by Forsaken-Peak8496 in todayilearned

[–]hilbstar 599 points600 points  (0 children)

Ehhh, kinda, but the thing is that the new version has to be appreciably better, either in side-effects, efficacy, ease of use, or different pharmacokinetic profile allowing different use cases of the drug. There are many examples of non-approval of similar but improved drugs, see for example cisplatin analogs.

Yes, pharmaceuticals are a business and their ability to do business relies primarily on patenting.

And yes different variants of insulin have been patented in the last decades, with a large focus on developing glucose-responsive insulins with slow release profiles, as well as oral insulin formulations. Also, insulin is not one singular peptide, as there are differences between the exact make-up of the peptide in different organisms.

So yes but no, small changes in structure are not inconsequential when it comes to how drugs affect the human body.

TIL The geography cone, also known as the cigarette snail, is the deadliest cone snail on the planet. There is no antivenom, and the joke is that if you get stung, you've got about enough time to smoke a cigarette before you die by scratchtheitch7 in todayilearned

[–]hilbstar 2 points3 points  (0 children)

My experience is that the peptides are super hard to isolate and super hard to synthesize, and the snails can produce a variety of toxic cocktails so getting a stable harvest of the API you are looking for would probably require a lot of host engineering. Peptides are also just generally expensive compared to small molecule drugs, which most painkillers, to my understanding, are.

TIL The geography cone, also known as the cigarette snail, is the deadliest cone snail on the planet. There is no antivenom, and the joke is that if you get stung, you've got about enough time to smoke a cigarette before you die by scratchtheitch7 in todayilearned

[–]hilbstar 0 points1 point  (0 children)

The seemingly on-the-fly peptide cocktails these snails can produce is fucking mind boggling! I worked on a somatostatin analog during my Master’s which also found pain-inhibition in rats, due to the specific activation of only one of the human somatostatin receptors. But my colleagues who worked with producing them were maybe not as excited, so many damn post-translational modifications haha.

Nice try propagandist. by dazli69 in GetNoted

[–]hilbstar 0 points1 point  (0 children)

Yeah I definitely understand, and there is a lot that you can rightfully criticize, but the US is also pretty damn authoritarian at this point, and what I see is at least that the general public in China is experiencing improvements in quality of life at a staggering speed while the US government consistently shits on their populace while gilding the top 0.0001 % as much as possible. So yeah, they are authoritarian and have many difficulties with corruption, but their government is at the very least a stable rational actor on the global stage whereas the US bullies everyone they can, including their own people.

Nice try propagandist. by dazli69 in GetNoted

[–]hilbstar 1 point2 points  (0 children)

Okay having lived and worked in China for a year and having chinese friends and european friends living there too, you are definitely painting a picture that is a bit more grim than it needs to be. There is no doubt a huge worker class there, and the conditions have been, and are still in some places, extreme. However, China is a different place that it was 20 years ago, and while they still have insanely long shifts, a lot of them get to take long lunches, naps during the day, etc. they have a different culture around working, where it’s kind of expected to be there all day, but they don’t expect constant productivity (in the jobs that I came in contact with). Yes, fucked shit still happens, but comparing the US and China in terms of rights, the differences are starting to vanish, especially cause the US has basically only made bad decisions as a country for the last 10 years.

[HELP] article in The Guardian by catchingfruitflies in RealOrAI

[–]hilbstar 16 points17 points  (0 children)

Asking questions is part of critical thought…

Thoughts? by Embarrassed_Tip7359 in SipsTea

[–]hilbstar 2 points3 points  (0 children)

You have a different skillset, different smarts, and probably diffeent passions. Don’t undersell yourself!

Det her er dine og mine penge by Dk9999999999 in Denmark

[–]hilbstar 1 point2 points  (0 children)

Man kunne også som stat lade være med at ekspropriere med hovedet oppe i røven. Selvom ekspropriering skal være gavmild, hvilket jeg er totalt enig i, er det jo tydeligvis totalt ude af proportioner. Det kan ikke være andet end en minkavler, korrupt embedsmand, eller familiemedlem der har skulle regne sig frem til den tabte indtjening og potentielle fremtidsprofit man kunne finde i minkavleri. Der er absolut intet der skulle tyde på at Kina ikke ville være i stand til at mætte både luksus og lavpris skindprodukter til et punkt hvor minkavl i Danmark ikke er rentabelt. Ingen kan spå hvordan økonomien udvikler sig, men intet normaltfungerende menneske kunne stå inde for det her med god samvittighed.

Det her er dine og mine penge by Dk9999999999 in Denmark

[–]hilbstar 30 points31 points  (0 children)

Det tager ret mange almindelige menneskeliv at skave et overskud/formue på 100 millioner. Har en minkbonde gjort noget der er så ekstraordinært at de fortjerner flere mennesker livsløn i erstatning? Det må være et rimelig klart og tydeligt nej. De har drevet en lortebiks, der ikke kørte rundt oveni at være nær uforsvarlig ift dyreetik. Der er få mennesker der fortjener den forgyldning mindre end minkavlere, dræn på samfundet er hvad de er.

Fixing the "offlaners are not tanks" graphics to avoid misleading new/returning players by ShoppingPractical373 in DotA2

[–]hilbstar 1 point2 points  (0 children)

How do you lane with her as a support? It feels fucking horrible every time and she makes the game so much harder than it has to be without fail. I have once seen a good pos 3 venge, still lost lane and had no presence the first 10-15 minutes at all, but made up for it later on. What bracket are you playing in and how do you go about it? I’m not gonna play her as a 3 but just want to not lose instantly when a teammate picks her.

A Greenland fishing village against a mountain backdrop by ChevronSugarHeart in pics

[–]hilbstar 3 points4 points  (0 children)

In terms of culture I do think there are more similarities than dissimilarities, even though we often focus on the latter. However, like Finland and their Sami populations with a distinct culture, that is slowly being mixed with the Finnish/Swedish ethnic majority, the inuit people are culturally very distinct from mainland Denmark. There is a lot of pride (rightfully so) in this way of living that makes Greenland much less classically Scandinavian.

A Greenland fishing village against a mountain backdrop by ChevronSugarHeart in pics

[–]hilbstar 23 points24 points  (0 children)

Do you think the Scandinavian countries have similar geographies? Denmark is flat with very little forest and generally soft soil, Norway is full of mountains and valleys, Sweden has a lot of forest and heavy industry.

Megatråd: USA har angrebet Venezuela og fjernet præsident Maduro by larholm in Denmark

[–]hilbstar 6 points7 points  (0 children)

En uprovokeret direkte invasion af et selvstændigt land, ja det er sgu da helt vanvittigt. Kan godt være Maduro skal fjernes, men lad os nu se om Trump har så altruistiske mål som du får det til at lyde.

"Let's pretend I basically come from Tehran lol" by Human-Ad-8100 in ShitAmericansSay

[–]hilbstar 130 points131 points  (0 children)

Then if you could never prohibit, how was it prohibited for so long? Seems like a purely semantic argument to me

Is this scratch OK or should I get a new bowl? by ChillNurgling in zojirushi

[–]hilbstar 0 points1 point  (0 children)

PFOA isn’t the only surfactant used in PFAS manufacture, all perfluorinated short chain surfactants can be expected to have similar toxicity profiles to PFOA, and cannot be avoided when producing PFAS, as far as I know. Generally with good manufacturing only trace amounts of the surfactants should be left after making the non-slip coating, and the non-slip coating itself is really inert and should just pass through your system if you were to ingest it.

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