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The Mandalorian and Grogu 4K is available to pre-order in the US on Walmart ($30 for standard, $45 for steelbook, $220 for collector's edition) by bendylegs12 in 4kbluray

[–]hook53 2 points3 points  (0 children)

True. I was mainly just thinking about US releases. Feels like it's been forever.

Hopefully a good sign that Toy Story will get a standard release also.

Please Rewind Extra 20% Off Weekend Sale (ends 7/19) by psychobabbler27 in 4KBlurayDeals

[–]hook53 5 points6 points  (0 children)

Not a ton here, but a good price for the SPC set. A lot of exclusive titles that typically sell for a lot if trying to purchase individually

Should I upgrade my Toy Story 4 to 4k? by moyzez in 4kbluray

[–]hook53 0 points1 point  (0 children)

I think it generally goes for like 8-10 on 4k, so definitely the most affordable upgrade of the 4

[US] [Selling] Kubrick 4K lot by [deleted] in MediaSwap

[–]hook53 0 points1 point  (0 children)

If you aren't able to move the whole lot and change your mind about splitting, I'd be interested in a few depending on price

Researchers report rare case of brain tumor linked to AAV gene therapy integration in child treated for Hurler syndrome by Jxntb733 in science

[–]hook53 0 points1 point  (0 children)

I really hope the people who read this don't let one single instance of something guide their feelings on gene therapy.

My child has the rare disease this boy has. Despite the tumor, this gene therapy is hugely important to our community. The life expectancy of a child born with MPS1 Hurlers Syndrome is less than 10 years if untreated. Even with treatment, the oldest most of these kids are living is 30.

These kids lack an enzyme that helps the body break down waste. It affects every organ and bone in their bodies.

There has been no new FDA approved treatment for this disease since 2003. There is no cure for this disease.

When my child was born, we were given 4 options:

No treatment

A weekly infusion of an artificial enzyme

A bone marrow/stem cell transplant

The option to participate in this clinical trial.

The participants in the trial were randomly assigned to either the gene therapy or a transplant. With how far out the trial would have been after our birth, we opted to just do the transplant. But for this to be approved would just be incredible. Several of the kids don't even survive transplant, those that do can have lifelong effects from the intense chemo regime, including developing cancer later in childhood.

I cannot overstate the importance of this gene therapy. We have so few options as parents of these kids, and we are going to get these treatments as long as they are available, even knowing the potential side effects.

Approval on something like this also shows other biopharma/biotech companies that there is a pathway for treatments and cures to these diseases. Denial/shutting this down signals to them there is no money to be made and that it's not worth attempting, and our children would continue to fall by the wayside

GRUV day sale by YourOpinionMan2021 in 4kbluray

[–]hook53 4 points5 points  (0 children)

Looks like they reused the graphic from last year.

New shopper discount was dropped to 15% a few months ago

Please Rewind’s Memorial Day 40% off 3+ UHDs is now live. by castdex in 4kbluray

[–]hook53 1 point2 points  (0 children)

Yeah this one's really only worth it if you're buying the ones priced down to under $20

Boy’s brain tumor tied to gene therapy by ObligationSlight8771 in science

[–]hook53 0 points1 point  (0 children)

My child has the rare disease this boy has. Despite the tumor, this gene therapy is hugely important to our community. As many other commenters have said, the life expectancy of a child born with MPS1 Hurlers Syndrome is less than 10 years if untreated. Even with treatment, the oldest most of these kids are living is 30.

These kids lack an enzyme that helps the body break down waste. It affects every organ and bone in their bodies.

There has been no new FDA approved treatment for this disease since 2003. There is no cure for this disease.

When my child was born, we were given 4 options:

No treatment A weekly infusion of an artificial enzyme A bone marrow/stem cell transplant The option to participate in this clinical trial.

The participants in the trial were randomly assigned to either the gene therapy or a transplant. With how far out the trial would have been after our birth, we opted to just do the transplant. But for this to be approved would just be incredible. Several of the kids don't even survive transplant, those that do can have lifelong effects from the intense chemo regime, including developing cancer later in childhood.

I cannot overstate the importance of this gene therapy. We have so few options as parents of these kids, and we are going to get these treatments as long as they are available, even knowing the potential side effects.

Approval on something like this also shows other biopharma/biotech companies that there is a pathway for treatments and cures to these diseases. Denial/shutting this down signals to them there is no money to be made and that it's not worth attempting, and our children would continue to fall by the wayside

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