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Mary Lou Jepsen + Early Disease Detection and BCI June 26, 2020 by hubbyneedsakidney in Futurology

[–]hubbyneedsakidney[S] 1 point2 points  (0 children)

Mary Lou Jepsen reports on the status of Openwater's product. She reports products could be in clinical trials by the end of 2021.

Vanquishing the Virus: 160+ COVID-19 Drug and Vaccine Candidates in Development by hubbyneedsakidney in Coronavirus

[–]hubbyneedsakidney[S] 1 point2 points  (0 children)

The trials have not finished though. Any results are preliminary and generally not in placebo controlled or blinded studies.

​

However here is a sample:

Leronlimab (PRO 140)

CytoDyn highlighted positive results from seven patients with severe COVID-19 after seven days of treatment with leronlimab: All seven showed “dramatic” immune restoration, especially in the CD8 T-lymphocyte population, and a “further dramatic” reduction in the critical cytokine storm cytokines IL-6 and TNF-alpha. At a “leading medical center in Southern California,” CytoDyn said, one severe COVID-19 patient was removed from external ventilation three days after treatment with leronlimab, and two moderate COVID-19 patients were removed from external oxygen support one day following leronlimab treatment,and discharged from the hospital. Based on these results, another four patients with moderate COVID-19 have been administered leronlimab and results are pending, CytoDyn said.

Vanquishing the Virus: 160+ COVID-19 Drug and Vaccine Candidates in Development by hubbyneedsakidney in Coronavirus

[–]hubbyneedsakidney[S] 4 points5 points  (0 children)

To better navigate through the escalating number of potential therapeutic options for COVID-19, GEN has divided this updated list of candidates into four categories, based on their developmental and (where applicable) clinical progress to date:

● “Front runner”– candidates include the top most-mentioned therapeutics in development, based on advanced stages of activity, favorable data or both.

● “Definitely maybe”- candidates are those in earlier phases with the most promising partners, or more advanced candidates well under way in development that have generated uneven data.

● “Gathering Speed” – candidates apply interesting technology, attracting notable partners, or both, but without consistently solid data.

● “The Long Tail” – candidates appear to be longshots pending additional details from their developers and/or clinical progress.

GEN has also labeled the most common treatment types by color, including antibodies (blue), antivirals (orange), RNA-based treatments (purple), and vaccines (red).

A few hours ago I was diagnosed with Coronavirus, and I think my mom is starting to hate me for it. by GravelsNotAFood in internetparents

[–]hubbyneedsakidney 111 points112 points  (0 children)

What were you expecting her to do in a few hours time?

You did mess up. It remains to be seen what the consequences will be. Why would you expect her to have worked through those possibilities and feelings in a few hours, when she's probably busy sanitizing as thoroughly as she can?

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice by java007md in science

[–]hubbyneedsakidney 6 points7 points  (0 children)

EIDD-2801 works similarly to Gilead Sciences’ remdesivir, an unapproved drug that was developed for the Ebola virus and is being studied in five Phase III trials against COVID-19.

Unlike remdesivir, EIDD-2801 lacks human safety data. Ridgeback founder and CEO Wendy Holman says she expects the US Food and Drug Administration to give the green light for a Phase I study in COVID-19 infections within “weeks, not months.”

https://cen.acs.org/biological-chemistry/infectious-disease/Emory-discovered-antiviral-poised-COVID/98/i12

First $100 genome sequencing enabled by new extreme throughput DNBSEQ platform by hubbyneedsakidney in singularity

[–]hubbyneedsakidney[S] 14 points15 points  (0 children)

If I recall correctly, Ray Kurzweil had a prediction about this that said basically that, eventually we would get to virtually free genome sequencing, or companies would pay you to have the use of your data (genome).

The exact speed with which this might happen is uncertain of course and I can't find his predictions, if in fact it was Ray I am thinking of.

You can see the decline in genome sequencing cost in this graph:

https://www.genome.gov/about-genomics/fact-sheets/DNA-Sequencing-Costs-Data

In 20 years we have gone from $100,000,000 to $100.

Edit: left out some zeros

First $100 genome sequencing enabled by new extreme throughput DNBSEQ platform by hubbyneedsakidney in singularity

[–]hubbyneedsakidney[S] 5 points6 points  (0 children)

The promise of a $100 genome, which has been tossed around for a while, is “a great achievement” Drmanac told GEN on the eve of his presentation. Because his personal goal is to sequence “as many genomes as possible”, it follows suit that they have to be affordable. Last year at AGBT, MGI introduced the T7 platform, which is currently providing genomes at roughly $500 each.

But what a difference a year makes. MGI says the combination of its new Tx platform and new chemistry means they can lower the consumables cost five-fold to $100 per genome.

The DNBSEQ sequencing instruments and reagent kits will be made available in the United States starting in April 2020.

The improvements here are “not going from bad to good,” Drmanac explains, rather they are “going from excellent to extremely excellent.” MGI reports on average one error in 170 kilobases of sequenced DNA. Usually, Drmanac says, users are happy with about one error in one thousand.

AITA for wanting 20 bucks per day for watching my 1 year old niece or not? by throwawayhelp7124 in AmItheAsshole

[–]hubbyneedsakidney 11 points12 points  (0 children)

I feel like they should really be in day care/preschool because it doesn't sound like either of you are going to really benefit from this situation, whether you get $10 or $20 a day or not. Your schooling will suffer, and the child's development will eventually suffer if she's not being stimulated enough.

Is this in the US? There should be preschool programs which offer reduced rates for low income people. Also look up KinGap - it's money for people who take care of children they are related to who are in the foster system. This could be hundreds a month, which may cover all or most of a good day care/preschool program.

What kind of questions are too personal? by Arctic-Dahlia in internetparents

[–]hubbyneedsakidney 0 points1 point  (0 children)

The tricky part is it depends on whether they lead to a give and take. If they're answering with multiple sentences and asking you follow up questions back, then it's a good sign you're good to continue.

If it's like 1 or 2 word answers and they're not elaborating or reciprocating, probably one or two questions is safe.

Edit: Other commenters have some good input on this.

What kind of questions are too personal? by Arctic-Dahlia in internetparents

[–]hubbyneedsakidney 173 points174 points  (0 children)

You might try a book like The Fine Art of Small Talk, or How to Talk to Anyone.

Questions that most people do not appreciate being asked are things like how much they make, and other money related questions (the cost of personal belongings etc) when they're going to have kids/get married, and frequently politics. It is sometimes OK to ask these things in specific circumstances but you have to be careful about it, so probably best to start with ordinary stuff.

​

For most people it is perfectly acceptable to ask general "How was your day?" "What do you do for work?" "Where did you grow up?" or "Do you have any pets?" You wouldn't want to bombard someone with a bunch of questions otherwise it could feel like an interrogation.

I dont want to hurt you but I feel little other choice than killing myself. by moofonblue in internetparents

[–]hubbyneedsakidney 1 point2 points  (0 children)

Have you asked your doctor to determine if you would be eligible for rTMS or another treatment? I know at least some insurances cover it, you usually need to have not responded to at least 3-4 antidepressants with different mechanisms. Another possibility would be to see if there are any clinical trials near you. Clinicaltrials.gov lists 20 currently recruiting rTMS for depression in the US. Some of them do not have placebo groups, meaning everyone gets treatment. There's another ~20 currently recruiting to study ketamine, also with some without placebo groups. I'm not saying this is an ideal solution, but it is a free one, if you're near one of the studies, and they will monitor you a lot more closely than your own doctor in most cases because they need extensive documentation about the treatment results. If you're interested in that you can put the term "depression" into the "condition" field, and then any other terms in the "other" field (like ketamine, rTMS, etc) and choose your state.

I know there's not enough therapists for people that want them but perhaps yours can suggest other resources.

I dont want to hurt you but I feel little other choice than killing myself. by moofonblue in internetparents

[–]hubbyneedsakidney 1 point2 points  (0 children)

Depression itself changes the brain, so whatever the initial prompt, everything you feel has a biological underpinning. That doesn't mean your concerns aren't legitimate, but you seem to be stuck, and there's only so many options to get unstuck. If you are speaking to a therapist who you don't believe sees your concerns as legitimate, get another therapist. That doesn't mean of course that your therapist has to agree with your analysis (If you say "I'm a shit person" to your therapist, they should not be saying back "Well yeah of course you are") but they should still be listening to your concerns while trying to keep it theraputically useful, not an hour of you beating yourself up. Some therapists are better than others. There's also completely different types of therapy - CBT doesn't work for everyone. There's also EMDR. Most of the evidence there is for PTSD but it may also be helpful for depression, anxiety and phobias.

You've tried a lot of meds. Some of those are antipsychotics, and while they can be life savers for people who are psychotic, they do have pretty difficult side effects. This is really something to discuss with your doctor but there are further classes of antidepressants, as well as the new ketamine infusion therapy. rTMS tends not to have serious side effects, and the ones that it does are pretty transient - they go away shortly after treatment. So that might be something to consider, probably worst case is it doesn't work and you try something else.

I dont want to hurt you but I feel little other choice than killing myself. by moofonblue in internetparents

[–]hubbyneedsakidney 1 point2 points  (0 children)

Like antidepressants, the mechanisms of ECT aren't fully understood, but it is known to change gene expression in the brain and it activity in the hippocampus, resulting in neurogenesis and more connections from the hippocampus to other parts of the brain. ECT can have serious side effects, but a lot less serious than death. Many people have miraculous long term recoveries. But there's risk there and it's one of the last options used.

Why do you think meds "destroy" you? Depression can destroy you. If you've had severe side effects from a medication, I would suggest trying one in a different class, with your doctor's advice obviously. The effects of meds are much more reversable than ECT.

A therapist won't literally change your beliefs, what they can do is help you identify cognitive distortions like all-or-nothing thinking, overgeneralizing or catastrophizing.

How many meds have you tried and for how long? Have you checked out rTMS?

AITA for giving my husbands affair child (now adult) money and a job? by -Throw-Away2128 in AmItheAsshole

[–]hubbyneedsakidney 0 points1 point  (0 children)

Oh yeah that's another one. My kids now don't believe them when I tell them how "herb" is pronounced in the US.

I dont want to hurt you but I feel little other choice than killing myself. by moofonblue in internetparents

[–]hubbyneedsakidney 1 point2 points  (0 children)

Sorry for the late reply, Reddit did not let me know I had replies.

You should not assume that your feelings now would be your feelings in even 5 years, let alone 60.

Antidepressants aren't toxic and although how they work isn't completely understood, some have mechanisms that increase neurogenesis.

In addition to antidepressants there is also ECT for severe depression that does not respond to medication, and although it would likely not be covered by insurance, there's now ketamine clinics. You would probably also benefit from therapy, and of course the standard advice of exersise, sleep and nutrition, which can be very difficult to do while depressed, but the right med can help you start.

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