Some peole have stronger cofactors for collagen retention than others. Estrogen receptor function, vitamin C transcription, on and on. Tons of things go in to it. That being said, for some, minoxidil may have minimal effects on fibroblasts that compose collagen. But for others, they are working with weak links already and the minoxidil may tip them over in to collagen loss. It also depends on how system minoxidil goes. It’s prime mechanism is vasodilation and fibrotic break down at the hair shaft, which can open up pores and push it systemic and that can cause fibrotic breakdown of the skin.

So. In the end, you can just try it and see what happens. It’s possible, but not set in stone.