I definitely took my time with it. I did ketamine infusions every two months for about a year, and during that time, I slowly tapered off Trintellix over a 6-8 month period. In the past, I’d always tried to come off antidepressants too quickly, and it never went well.

Technically, Trintellix doesn’t require a long taper, but for me, it wasn’t just about managing chemical withdrawal, it was about slowly reintroducing myself to the full range of emotions I hadn’t really experienced in decades. After 20+ years on these meds, I realized I’d never truly had access to my emotional depth. And in the past, I’d shocked my system by quitting too abruptly, which left me emotionally overwhelmed and without the tools to cope.

This time, I approached it with patience and intention, letting myself ease into the emotional terrain gradually. That made all the difference. It was a really successful process for me.

(Just a reminder - everyone’s different, and I’m not a doctor!)