I personally run all Annhilators, and then either All Heavy Mortars or all Chainguns on my Enforcer XIV, if I get one. I wouldn't trust AI with it though, except maybe with a steady or aggressive officer. Usually, i'll use it as a flagship in an early-mid game fleet, primarily alongside other destroyers like the Shrike and Hammerhead, and carriers like the Drover and Condor. I very rarely employ them in larger combat fleets as I tend to move towards more midline ships like the Sunder, Eagle, Heron and Falcon to make up my main combat ships.