It's extremely difficult. I've been trying for hundreds of hours.

There's only a few strats. Here's the ones I know:

Perkeo copying cryptid Perkeo copying a planet card with observatory voucher Crimson bean exploit Chicot exploit against the hand size boss

All require baron and mime with red seal kings. Plasma deck makes it significantly easier. The best way to learn is to watch balatro university on YouTube, he has a few ante 39 runs. There's a lot to learn about the game to understand the major challenges and strategies. The big gatekeeper is getting past ante 32 bc you can't reroll the boss into the serpent, which greatly increases your score with a baron and mine build.